宫颈高危型人乳头瘤病毒感染的中医证候特征研究  

Study on Traditional Chinese Medicine Syndrome Characteristics of Patients with Cervical High-Risk Human Papillomavirus Infection

作　　者：王嫱 郭洁[2] 宋殿荣[2] 鲁娣 WANG Qiang;GUO Jie;SONG Dian-Rong;LU Di(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;The Second Affiliated Hospital of TianjinUniversity of Traditional Chinese Medicine,Tianjin 300250,China)

机构地区：[1]天津中医药大学,天津301617 [2]天津中医药大学第二附属医院,天津300250

出　　处：《广州中医药大学学报》2024年第7期1669-1675,共7页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：天津市医学重点学科(专科)建设项目(编号:TJYXZDXK-023A);天津中医药大学第二附属医院青苗计划(编号:QMJH202102)。

摘　　要：【目的】探究宫颈高危型人乳头瘤病毒(HR-HPV)感染者中医证候特征,为临床辨证论治提供参考。【方法】收集2020年9月至2022年10月于天津中医药大学第二附属医院妇科就诊行HPV检测确诊为宫颈HR-HPV感染者进行中医证候调查,总结其病位、病性特点及证型分布。【结果】宫颈HR-HPV感染者的临床特征主要以阴道分泌物异常为主,占63.40%。病位证素为胞宫、脾、肝、肾、经络、胃、心神、心,其中以胞宫、脾、肝最多见,分别占67.00%、58.80%和55.80%。病性证素为湿、热、气滞、血瘀、气虚、阳虚、阴虚、痰、寒,其中以湿、热、气滞、血瘀最多见,分别占66.40%、56.60%、36.00%和31.80%。各年龄段病位证素均以胞宫为主,病性证素均以湿、热为主。双病位证素以胞宫-脾最常见,三病位证素以胞宫-脾-肝最常见。双病性证素以湿-热最常见,三病性证素以湿-热-血瘀最常见。根据聚类分析结果,结合临床实际,发现宫颈HR-HPV感染者的主要证型分布为湿热瘀阻、肝郁气滞、心肾不交、脾胃阳虚。【结论】宫颈HR-HPV感染者的中医病位证素主要在胞宫,兼脾、肝、肾多脏腑合病;病性证素以湿、热为主,呈现虚实错杂的特点;中医证型主要是湿热瘀阻、肝郁气滞、心肾不交、脾胃阳虚。Objective To explore the characteristics of traditional Chinese medicine(TCM) syndromes in patients with cervical high-risk human papillomavirus(HR-HPV) infection,and to provide reference for clinical syndrome differentiation and treatment of cervical HR-HPV patients.Methods From September 2020 to October 2022,the TCM syndrome manifestations of cervical HR-HPV infection diagnosed by HPV detection in the Gynecology Department of The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine were investigated,and then the distribution of disease-location syndrome elements,disease-nature syndrome elements and syndrome types was analyzed.Results The patients with cervical HR-HPV infection were usually manifested with abnormal vaginal secretions,which accounted for 63.40%.The disease-location syndrome elements of cervical HR-HPV infection were uterus,spleen,liver,kidney,meridians,stomach,heart spirit and heart.Among them,uterus,spleen and liver were most commonly-seen,accounting for 67.00%,58.80% and 55.80%respectively.The disease-nature syndrome elements were dampness,heat,qi stagnation,blood stasis,qi deficiency,yang deficiency,yin deficiency,phlegm and cold.Among them,dampness,heat,qi stagnation and blood stasis were most commonly-seen,accounting for 66.40%,56.60%,36.00% and 31.80%,respectively.In various age groups of the infected patients,the uterus was the predominated disease-location syndrome element,and dampness and heat were the predominated disease-nature syndrome elements.The uterus-spleen was the predominated double disease-location syndrome element,and the uterus-spleen-liver was the predominated triple disease-location syndrome element.Damp-heat was the predominated double disease-nature syndrome element,and damp-heat-blood stasis was the predominated triple disease-nature syndrome element.According to the results of cluster analysis and with reference to the clinical practice,it was found that the main syndrome types of the patients with cervical HR-HPV infection were damp-heat st

关 键 词：人乳头瘤病毒(HPV)感染 高危型人乳头瘤病毒(HR-HPV) 中医证候特征 证素 胞宫 湿热瘀阻 肝郁气滞 心肾不交 脾胃阳虚 

分 类 号：R271.9[医药卫生—中西医结合]