通元针法联合加味苓桂术甘汤治疗脾虚痰湿型多囊卵巢综合征的临床观察  

Clinical Observation on the Tongyuan Acupuncture Combined with Modified Linggui Zhugan Decoction in the Treatment of Polycystic Ovary Syndrome with Spleen Deficiency and Phlegm-Damp Syndrome

作　　者：周罗林 周俊亮[1,2] 谭兴举 李月梅 罗玳红 ZHOU Luo-Lin;ZHOU Jun-Liang;TAN Xing-Ju;LI Yue-Mei;LUO Dai-Hong(Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China;Nanhai Maternity and Children’s Hospital Affiliated to Guangzhou University of Chinese Medicine(Foshan Nanhai District Women and Children Hospital),Foshan 528299 Guangdong,China;Guangzhou Eighth Hospital Affiliated to Guangzhou Medicine University,Guangzhou 510440 Guangdong,China;Shenzhen Hospital of Beijing University of Chinese Medicine(Longgang),Shenzhen 518172 Guangdong,China)

机构地区：[1]广州中医药大学,广东广州510006 [2]广州中医药大学附属南海妇产儿童医院(佛山市南海区妇幼保健院),广东佛山528299 [3]广州医科大学附属市八医院,广东广州510440 [4]北京中医药大学深圳医院(龙岗),广东深圳518172

出　　处：《广州中医药大学学报》2024年第7期1792-1797,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药管理局科研资助项目(编号:20241246);佛山市科技局科研资助项目(编号:2220001004227);广东省教育厅普通高校认定类科研项目(编号:2021WQNCX205)。

摘　　要：【目的】观察通元针法联合加味苓桂术甘汤治疗脾虚痰湿型多囊卵巢综合征(PCOS)的临床疗效。【方法】将86例脾虚痰湿型PCOS患者随机分为观察组和对照组,每组各43例。对照组给予盐酸二甲双胍联合炔雌醇环丙孕酮片治疗,观察组在对照组治疗的基础上,给予通元针法联合加味苓桂术甘汤治疗,2组患者均持续治疗3个月。治疗3个月后,评价2组临床疗效,观察2组患者治疗前后性激素指标雌二醇(E2)、睾酮(T)、促黄体生成激素(LH)、促卵泡生成激素(FSH)、催乳激素(PRL)表达水平的变化情况,比较2组患者治疗前后糖代谢水平包括胰岛素抵抗指数(HOMA-IR)、空腹胰岛素(FINS)、空腹血糖(FPG)表达水平的变化情况。【结果】(1)观察组总有效率为90.70%(39/43),对照组为74.42%(32/43)。观察组疗效优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的HOMA-IR、FINS、FPG水平均明显改善(P<0.05),且观察组在改善HOMA-IR、FINS、FPG水平方面明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,2组患者E2、T、LH、FSH、PRL水平均明显改善(P<0.05),且观察组在改善患者E2、T、LH、FSH、PRL水平方面明显优于对照组,差异均有统计学意义(P<0.05)。【结论】通元针法联合加味苓桂术甘汤治疗脾虚痰湿型PCOS,可有效改善患者性激素水平,调节患者机体糖代谢,临床疗效显著。Objective To observe the clinical effect of Tongyuan Acupuncture combined with Modified Linggui Zhugan Decoction in the treatment of polycystic ovary syndrome(PCOS) with spleen deficiency and phlegm-damp syndrome.Methods A total of 86 patients with PCOS of spleen deficiency and phlegm-damp type were randomly divided into observation group and control group,43 cases in each group.The control group was treated with Metformin Hydrochloride Tablets combined with Ethinylestradiol and Cyproterone Acetate Tablets.The observation group was treated with Tongyuan Acupuncture combined with Modified Linggui Zhugan Decoction on the basis of the treatment of the control group.Both groups were treated for three consecutive months.After three months of treatment,the clinical efficacy of the two groups was evaluated.The changes of sex hormone indexes estradiol(E2),testosterone(T),luteinizing hormone(LH),follicle stimulating hormone(FSH) and prolactin(PRL) expression levels were observed before and after treatment in the two groups.The changes of glucose metabolism levels including insulin resistance index(HOMA-IR),fasting insulin(FINS) and fasting blood glucose(FPG) expression levels were compared before and after treatment between the two groups.Results(1) The total effective rate was 90.70%(39/43) in the observation group and 74.42%(32/43) in the control group.The curative effect of the observation group was superior to that of the control group,and the difference was statistically significant(P<0.05).(2) After treatment,HOMA-IR,FINS and FPG in the two groups were significantly improved(P<0.05),and the improvement of HOMA-IR,FINS and FPG in the observation group was superior to that in the control group,the difference being significant(P<0.05).(3) After treatment,the levels of E2,T,LH,FSH and PRL in the two groups were significantly improved(P<0.05),and the levels of E2,T,LH,FSH and PRL in the observation group were significantly superior to those in the control group,the differences were statistically significant(P<0.05).Concl

关 键 词：通元针法 加味苓桂术甘汤 脾虚痰湿型 多囊卵巢综合征 性激素 糖代谢 临床观察 

分 类 号：R246.9[医药卫生—针灸推拿学]