3D生物打印在肾脏再生领域的研究进展  

Advances in 3D bioprinting in the field of kidney regeneration

作　　者：郭煦妍 罗志嵘 薛琦 王林猛 吉运华 张波 Xuyan Guo;Zhirong Luo;Qi Xue;Linmeng Wang;Yunhua Ji;Bo Zhang(Department of Urology,Tangdu Hospital of Air Force Military Medical University,Xi'an 710032,China)

机构地区：[1]空军军医大学唐都医院泌尿外科,西安710032

出　　处：《中华细胞与干细胞杂志（电子版）》2024年第3期181-185,共5页Chinese Journal of Cell and Stem Cell（Electronic Edition）

摘　　要：慢性肾脏病(CKD)的发病率在全球范围内持续上升,进一步可发展为终末期肾病(ESRD)。针对ESRD患者,透析或肾移植一直作为主要的临床治疗方法。然而,透析治疗可能会导致一系列并发症,同时会对患者的生活方式和社交活动造成限制。肾移植是ESRD另一种可行的治疗选择,但由于供体短缺和排斥反应等问题受到限制。因此,许多有关肾脏再生的策略正在研究中。3D生物打印作为一种组织工程技术,已在体外肾组织模型和类肾结构的制造方面取得了进展。它有望通过制造人造器官(组织)来解决器官供体短缺的问题。虽然该技术已适应各种细胞类型和生物材料,但目前仍然需要解决许多问题。例如细胞和生物材料的选择以及模拟血管网络。本文旨在综述3D生物打印在肾脏再生领域的最新进展,包括常用的3D生物打印技术和生物材料的选择、3D生物打印生成部分肾单位以及面临的挑战和未来发展方向。The incidence of chronic kidney disease(CKD)continues to increase globally and progresses to end-stage renal disease(ESRD).For patients with ESRD,dialysis or kidney transplantation has always been the leading clinical treatment.However,dialysis treatment is associated with several complications and limits a patient's lifestyle and social activities.Kidney transplantation is another viable treatment option for ESRD but is limited due to issues such as donor shortage and rejection.Therefore,many strategies for kidney regeneration are under investigation.As a tissue engineering technology,3D bioprinting has made progress in fabricating in vitro kidney tissue models and kidney-like structures.It is expected to solve the problem of organ donor shortage by creating artificial organs/tissues.While the technology has been adapted to a variety of cell types and biomaterials,many issues still need to be addressed.Examples include cell and biomaterial selection and simulating vascular networks.This article aims to review the latest progress of 3D bioprinting in the field of kidney regeneration,including commonly used 3D bioprinting technologies and biomaterial selection,3D bioprinting to generate partial nephrons,and challenges and future development directions.

关 键 词：3D生物打印 生物墨水 肾细胞 诱导性多能干细胞 

分 类 号：R318.1[医药卫生—生物医学工程] R692[医药卫生—基础医学]