退变性腰椎侧凸遗传易感性的研究进展  

Research progress of genetic predisposition to degenerative lumbar scoliosis

作　　者：商振国 李泽群 王辉[1] 丁文元[1] SHANG Zhenguo;LI Zequn;WANG Hui;DING Wenyuan(Department of Spine Surgery,Third Hospital of Hebei Medical University,Shijiazhuang 050051,China;Department of Computed Tomography,Third Hospital of Hebei Medical University,Shijiazhuang 050051,China)

机构地区：[1]河北医科大学第三医院脊柱外科,河北石家庄050051 [2]河北医科大学第三医院CT室,河北石家庄050051

出　　处：《大连医科大学学报》2024年第3期242-246,253,共6页Journal of Dalian Medical University

基　　金：河北省自然科学基金项目(H2022206056)。

摘　　要：退变性腰椎侧凸(degenerative lumbar scoliosis,DLS)是一种主要发生于成年人的脊柱畸形,其特点是椎间盘和小关节不对称性退变,导致脊柱不平衡,引发严重的疼痛和神经功能损伤,从而使患者生活质量显著降低。DLS可能是由环境因素和遗传易感性共同引起,但驱动DLS的分子机制仍不明确。本文重点对DLS特有的表观遗传和/或遗传驱动因素,以及该领域当前的局限性和挑战进行综述。Degenerative lumbar scoliosis(DLS)is a spinal deformity that occurs primarily in adults.It is characterized by asymmetric degeneration of intervertebral discs and facet joints,leading to spinal imbalance that can result in severe pain and neurological deficits,thus significantly reducing the quality of life.DLS is likely caused by a combination of environmental factors and genetic predisposition.However,the molecular mechanisms driving DLS remain unclear.The focus of this article is to provide an overview of the specific epigenetic and/or genetic factors driving DLS and current challenges in the field,in order to provide a theoretical reference for future research.

关 键 词：退变性腰椎侧凸 遗传易感性 分子机制 蛋白 

分 类 号：R681.5[医药卫生—骨科学]