香豆素类天然产物Murraol和(E)-Suberenol的合成研究  

Synthesis of the Natural Coumarin Products Murraol and(E)-Suberenol

作　　者：刘致文 公绪顺 张凯 雷婷 江世智 Liu Zhiwen;Gong Xushun;Zhang Kai;Lei Ting;Jiang Shizhi(College of Pharmacy,Dali University,Dali,Yunnan 671000,China;Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan,Dali,Yunnan 671000,China)

机构地区：[1]大理大学药学院,云南大理671000 [2]云南省滇西抗病原植物资源筛选研究重点实验室,云南大理671000

出　　处：《大理大学学报》2024年第8期14-19,共6页Journal of Dali University

基　　金：国家自然科学基金项目(22361002);云南省地方本科高校基础研究联合专项资金项目(202101AO070315);云南省科技厅基础研究专项资金项目(202201AT070175)。

摘　　要：目的:一步高效地合成香豆素类天然产物Murraol和(E)-Suberenol,为类似天然产物的合成提供有力支撑。方法:以溴代香豆素为原料,通过过渡金属钯催化的Heck偶联反应合成香豆素类天然产物Murraol和(E)-Suberenol。结果:高效、简捷地完成了2个香豆素类天然产物Murraol和(E)-Suberenol的合成。结论:该合成方法具有操作简单、反应条件温和、符合原子经济性的特点,适用于工业化生产。Objective:To efficiently synthesize the natural coumarin products Murraol and(E)-Suberenol in a single step,and provide strong support for the synthesis of similar natural products.Methods:Using brominated coumarin as the starting material,the natural coumarin products Murraol and(E)-Suberenol were synthesized by Heck coupling reaction catalyzed by transition metal palladium.Results:The synthesis of both natural coumarin products Murraol and(E)-Suberenol were efficiently and straightforwardly achieved.Conclusion:The synthetic method has the characteristics of simple operation,mild reaction conditions and atomic economy,and is suitable for industrial production.

关 键 词：香豆素 过渡金属钯催化 HECK偶联反应 

分 类 号：TQ463[化学工程—制药化工]