Predictive value of total cholesterol to high-density lipoprotein cholesterol ratio for chronic kidney disease among adult male and female in Northwest China  

作　　者：Yanli Liu Kang Lyu Shaodong Liu Jinlong You Xue Wang Minzhen Wang Desheng Zhang Yana Bai Chun Yin Min Jiang Shan Zheng 

机构地区：[1]School of Public Health,Institute of Epidemiology and Statistics,Lanzhou University,Lanzhou,Gansu,China [2]Workers'Hospital of Jinchuan Group Co.Ltd.,Jinchang,Gansu,China [3]Wuwei People's Hospital,Wuwei,Gansu,China

出　　处：《Chronic Diseases and Translational Medicine》2024年第3期216-226,共11页慢性疾病与转化医学（英文版）

基　　金：Municipal Science and Technology Program of Wuwei City, China(Grant/Award Number: WW2202RPZ037);Fundamental Research Funds for the Central Universities in China(Grant/Award Number: lzujbky-2018-69)。

摘　　要：Background: Studies have found that the ratio of total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C) was associated with the development of chronic kidney disease (CKD). However, the relationship in different genders was rarely discussed. The aim of this study was to explore this relationship and assess its predictive power for both males and females.Methods: Based on a prospective cohort platform in northwest China, 32,351 participants without CKD were collected in the baseline and followed up for approximately 5 years. Cox proportional hazard model and restricted cubic spline regression analysis were performed to investigate the association between TC, HDL-C, TC/HDL-C and CKD in adult female and male. The clinical application value of the indicators in predicting CKD was evaluated by the receiver operator characteristic curve.Results: During a mean follow-up of 2.2 years, 484 males and 164 females developed CKD. After adjusted for relevant confounders, for every one standard deviation increase in TC, HDL-C and TC/HDL-C, the hazard ratios (HRs) and 95% confidence intervals (95% CIs) for CKD were 1.17 (1.05-1.31), 0.84 (0.71-0.99), and 1.15 (1.06-1.25) for males, 0.94 (0.78-1.13), 0.58 (0.35-0.95), and 1.19 (1.01-1.40) for females, respectively. The results also showed that TC, HDL-C, and TC/HDL-C were associated with CKD in a linear dose-response relationship. The TC/HDL-C had the largest area under the curve (AUC) compared to TC and HDL-C, and the AUC among the females was larger than that among males.Conclusions: The TC/HDL-C was significantly associated with CKD in adult males and females and has better clinical value in predicting CKD than TC and HDL-C, especially in females.

关 键 词：chronic kidney disease GENDER Jinchang Cohort predictive value TC/HDL-C 

分 类 号：R692[医药卫生—泌尿科学]