裸盖菇素对小鼠社交行为调控作用研究  

Regulatory effects of psilocybin on social behavior in mice

作　　者：雷鑫 李燊 王禹霏 夏文龙 吴燕 赵哲 吴海涛[1,2] LEI Xin;LI Shen;WANG Yufei;XIA Wenlong;WU Yan;ZHAO Zhe;WU Haitao(School of Basic Medicine,Qingdao University,Qingdao,Shandong 266071,China;Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China;School of Information Science and Engineering,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]青岛大学基础医学院,山东青岛266071 [2]军事科学院军事医学研究院,北京100850 [3]兰州大学信息科学与工程学院,兰州730000

出　　处：《军事医学》2024年第6期407-413,共7页Military Medical Sciences

基　　金：国家自然科学基金项目(32171148,32325025);科技创新2030-脑科学与类脑研究重大项目(2021ZD0202500);科技部重点研发专项(2021YFA1101801)。

摘　　要：目的 评价裸盖菇素对C57BL/6J雄性小鼠社交行为的调控作用。方法 成年雄性C57BL/6J小鼠腹腔注射低、中、高剂量裸盖菇素(0.2、1和5 mg/kg,i.p.),采用三箱亲社会行为评价裸盖菇素对社交能力的影响。对经历慢性社会挫败(CSDS)的焦虑模型小鼠急性腹腔注射中剂量裸盖菇素(1 mg/kg),采用改良型两箱社交行为学评价小鼠社交新颖性偏好行为的改变。结果 在亲社会行为学实验中,腹腔注射中剂量裸盖菇素(1 mg/kg)促进小鼠亲社会行为,延长社交时间(P<0.01),腹腔注射低剂量裸盖菇素(0.2 mg/kg)对小鼠亲社会行为时间无明显影响,腹腔注射裸盖菇素(5 mg/kg)对小鼠亲社会行为表现出先抑制后促进作用。进一步研究发现,腹腔注射裸盖菇素(1 mg/kg)可增加经历慢性社会挫败应激模型小鼠社交新颖性探索时间。结论 1 mg/kg剂量裸盖菇素可促进小鼠产生亲社会效应,对慢性社会挫败应激小鼠的社交新颖性偏好行为缺陷具有潜在改善作用。Objective To evaluate the regulatory effects of psilocybin on social behavior of male C57BL/6J mice.Methods Adult male C57BL/6J mice were intraperitoneally injected with psilocybin(0.2,1 and 5 mg/kg,i.p.),and the effects of psilocybin on prosocial behavior were evaluated by the three-chamber test.Stressed mice undergoing chronic social defeat stress(CSDS)were given acute intraperitoneal injection of psilocybin(1 mg/kg)to evaluate the moderation of social novelty preference behavior using the modified two-chamber test.Results Intraperitoneal injection of psilocybin(1 mg/kg)promoted prosocial behavior and prolonged social time(P<0.01),while intraperitoneal injection of psilocybin(0.2 mg/kg)had no apparent effect on the prosocial behavior of mice,and intraperitoneal injection of psilocybin(5 mg/kg)inhibited prosocial behavior before promoting it.Further studies showed that intraperitoneal injection of psilocybin(1 mg/kg)increased the social novelty exploration time in stressed mice undergoing CSDS.Conclusion This study shows that 1 mg/kg dose of psilocybin can promote the prosocial behavior in mice,and potentially ameliorate the deficit of social novelty preference behavior in CSDS mice.

关 键 词：裸盖菇素 亲社会行为 三箱社交 两箱社交 

分 类 号：R285[医药卫生—中药学] R749.4[医药卫生—中医学]