外泌体在脓毒症及相关器官损伤中的作用研究进展  

Research progress of exosomes in sepsis and related organ damage

作　　者：王梓含 翟科蓉 唐玉彬 李勇 Wang Zihan;Zhai Ke'rong;Tang Yubin;Li Yong(Department of Emergency Medicine,the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army,Lanzhou 730000,Gansu,China;Lanzhou University Second Hospital,Lanzhou 730000,Gansu,China)

机构地区：[1]解放军联勤保障部队第九四〇医院急诊医学科,甘肃兰州730000 [2]兰州大学第二临床医学院,甘肃兰州730000

出　　处：《中国中西医结合急救杂志》2024年第2期251-256,共6页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：甘肃省兰州市科技计划项目(2021-1-103)。

摘　　要：脓毒症是重症监护病房(ICU)患者的主要死亡原因之一,通常是由于感染诱导体内炎症过度激活,引起多器官功能衰竭并危及生命。外泌体是一种由细胞分泌的脂质双分子层纳米颗粒,并参与脓毒症的发生发展过程,外泌体携带的多种分子物质已被证明可以调节脓毒症相关炎症及器官损伤。特别是多种不同类型外泌体有望成为脓毒症诊断的标志物,也有望为改善脓毒症患者预后提供新的治疗靶点。现就外泌体与脓毒症、外泌体与脓毒症相关性急性肺损伤(SA-ALI)、外泌体与脓毒症相关性脑病(SAE)、外泌体与脓毒症相关性急性肾损伤(SA-AKI)、外泌体与脓毒性心肌病(SIC)、外泌体与脓毒症相关的其他器官损伤关系的研究进展进行回顾性分析,以帮助指导临床诊断和治疗。Sepsis is one of the leading causes of death in intensive care unit(ICU)patients,typically resulting from excessive inflammation induced by infection,leading to multiple organ dysfunction syndrome and life-threatening complications.Exosomes are a type of extracellular vesicle that are lipid bilayered nanoparticles secreted by cells.In recent years,numerous studies have demonstrated their involvement in the occurrence and development of sepsis.The various molecular substances carried by exosomes have been shown to regulate sepsis-related inflammation and organ damage.In particular,different types of exosomes hold promise as diagnostic biomarkers for sepsis patients,and also provide new therapeutic targets for improving patient outcomes.This review was conducted on the research progress concerning the relationship between exosomes and sepsis,sepsis associated-acute lung injury(SA-ALI),sepsis associated encephalopathy(SAE),sepsis associated-acute kidney injury(SA-AKI),sepsis associated cardiomyopathy(SIC),and other organ injuries related to sepsis.This study aims to assist in guiding clinical diagnosis and treatment.

关 键 词：外泌体 脓毒症 多器官损伤 诊断标志物 治疗靶点 

分 类 号：R631[医药卫生—外科学]