Brain development in newborns and infants after ECMO  

作　　者：Kai Yan Lu-Kun Tang Fei-Fan Xiao Peng Zhang Guo-Qiang Cheng Lai-Shuan Wang Chun-Mei Lu Meng-Meng Ge Li-Yuan Hu Yuan-Feng Zhou Tian-Tian Xiao Yan Xu Zhao-Qing Yin Gang-Feng Yan Guo-Ping Lu Qi Li Wen-Hao Zhou 

机构地区：[1]Department of Neonatology,Children Hospital of Fudan University,Shanghai 201102,China [2]Kunming Medical University Affiliated Dehong Hospital,Dehong,Yunnan,China [3]Graduate School,Kunming Medical University,Kunming,Yunnan,China [4]Department of Neurology,Children's Hospital of Fudan University,Shanghai,China [5]School of Medicine,Chengdu Women's and Children's Central Hospital,University of Electronic Science and Technology of China,Chengdu,Sichuan,China [6]Department of Intensive Care Medicine,Children's Hospital of Fudan University,Shanghai,China [7]Department of Intensive Care Medicine,The Sixth Medical Center of PLA General Hospital,Beijing,China [8]Key Laboratory of Neonatology,National Health Care Commission,Shanghai,China

出　　处：《World Journal of Pediatrics》2024年第6期556-568,共13页世界儿科杂志（英文版）

基　　金：funded by the National Natural Science Foundation of China(Grant number:82001599);Medical Innovation Research Program of Shanghai,China(Grant number:21Y11907200);Clinical Research Special Project of Shanghai Municipal Health Commission,China(Grant number:202140443).

摘　　要：Background Extracorporeal membrane oxygenation(ECMO)not only significantly improves survival rates in severely ill neonates but also is associated with long-term neurodevelopmental issues.To systematically review the available literature on the neurodevelopmental outcomes of neonates and infants who have undergone ECMO treatment,with a focus on motor deficits,cognitive impairments,sensory impairments,and developmental delays.This review aims to understand the incidence,prevalence,and risk factors for these problems and to explore current nursing care and management strategies.Data sources A comprehensive literature search was performed across PubMed,EMBASE,and Web of Science using a wide array of keywords and phrases pertaining to ECMO,neonates,infants,and various facets of neurodevelopment.The initial screening involved reviewing titles and abstracts to exclude irrelevant articles,followed by a full-text assessment of potentially relevant literature.The quality of each study was evaluated based on its research methodology and statistical analysis.Moreover,citation searches were conducted to identify potentially overlooked studies.Although the focus was primarily on neonatal ECMO,studies involving children and adults were also included due to the limited availability of neonate-specific literature.Results About 50%of neonates post-ECMO treatment exhibit varying degrees of brain injury,particularly in the frontal and temporoparietal white matter regions,often accompanied by neurological complications.Seizures occur in 18%–23%of neonates within the first 24 hours,and bleeding events occur in 27%–60%of ECMO procedures,with up to 33%potentially experiencing ischemic strokes.Although some studies suggest that ECMO may negatively impact hearing and visual development,other studies have found no significant differences;hence,the influence of ECMO remains unclear.In terms of cognitive,language,and intellectual development,ECMO treatment may be associated with potential developmental delays,including lower composite s

关 键 词：Brain development EXTRACORPOREAL membrane OXYGENATION INFANTS NEONATES NEUROLOGICAL outcomes 

分 类 号：R722.1[医药卫生—儿科]