Interaction between ozone and paternal smoking on fetal congenital heart defects among pregnant women at high risk a multicenter maternal-fetal medicine study  

作　　者：Huan Wang Yan-Ping Ruan Sheng Ma Ya-Qi Wang Xiao-Yu Wan Yi-Hua He Jing Li Zhi-Yong Zou 

机构地区：[1]Institute of Child and Adolescent Health,School of Public Health,National Health Commission Key Laboratory of Reproductive Health,Peking University,No.38 Xueyuan Rd,Haidian District,Beijing 100191,China [2]Echocardiography Medical Center,Beijing Anzhen Hospital.Capital Medical University,Maternal-Fetal Medicine center in Fetal Heart Disease,Beijing Anzhen Hospital,No.2 Anzhen Rd,Chaoyang District,Beijing 100029,China

出　　处：《World Journal of Pediatrics》2024年第6期621-632,共12页世界儿科杂志（英文版）

基　　金：supported by the National Natural Science Foundation of China(82073573 to ZZY,U21A20523 to HYH);the Beijing Key Laboratory of Maternal-Fetal Medicine in Fetal Heart Disease(BZ0308 to HYH);the National Key Research and Development Program of China(2022YFC3703502 to LJ).

摘　　要：Background Evidence remains limited on the association between maternal ozone(O,)exposure and congenital heart defects(CHDs)in offspring,and few studies have investigated the interaction and modification of paternal smoking on this association.Methods Using a sample including pregnant women at high risk of fetal CHD(with metabolic disease,first-trimester viral infection,family history of CHD,etc.)from a maternal-fetal medicine study covering 1313 referral hospitals in China during 2013-2021,we examined the associations between maternal O_(3)exposure during 3-8 weeks of gestational age and fetal CHD in offspring and investigated the interaction and modification of paternal smoking on this association.CHD was diagnosed by fetal echocardiograms,maximum daily 8-hour average O,exposure data at a 10 km×10 km spatial resolution came from the Tracking Air Pollution in China dataset,and paternal smoking was collected using questionnaires.Logistic regression models were used to estimate adjusted odds ratios(ORs)and 95%confidence intervals(CIs).Results Among 27,834 pregnant women at high risk of fetal CHD,17.4%of fetuses were diagnosed with CHD.Each 10μg/m^(3)increase in maternal O_(3)exposure was associated with a 17%increased risk of CHD in offspring(OR=1.17,95%CI=1.14-1.20).Compared with paternal nonsmoking and maternal low O_(3)exposure,the ORs(95%CI)of CHD for smoking and low O_(3)exposure,nonsmoking and high O_(3)exposure,and smoking and high O_(3)exposure were 1.25(1.08-1.45),1.81(1.56-2.08),and 2.23(1.84-2.71),respectively.Paternal smoking cessation seemingly mitigated the increased risk of CHD.Conclusions Maternal O_(3)exposure and paternal smoking were interactively associated with an increased risk of fetal CHD in offspring,which calls for effective measures to decrease maternal exposure to O_(3)pollution and secondhand smoke for CHDprevention.

关 键 词：Congenital heart defects Fetal heart development Ozone exposure Tobacco smoking 

分 类 号：R725.4[医药卫生—儿科]