LXA4、SAA、ECP水平预测咳嗽变异性哮喘患儿预后的价值  

Predictive value of LXA4,SAA,and ECP levels in the prognosis of children with cough variant asthma

作　　者：王雪红[1] 张延峰[1] 陈丹 白媛[2] 王栋梅[1] 李二乐 Wang Xuehong;Zhang Yanfeng;Chen Dan;Bai Yuan;Wang Dongmei;Li Erle(Department of Pediatrics,Yan'an People's Hospital,Yan'an Shaanxi 716000,China;Department of Neonatology,Yan'an University Affiliated Hospital,Yan'an Shaanxi 716000,China;Department of Otolaryngology,Yan'an People's Hospital,Yan'an Shaanxi 716000,China)

机构地区：[1]陕西省延安市人民医院儿科,陕西延安716000 [2]延安大学附属医院新生儿科,陕西延安716000 [3]陕西省延安市人民医院耳鼻喉科,陕西延安716000

出　　处：《保健医学研究与实践》2024年第6期80-84,共5页Health Medicine Research and Practice

基　　金：陕西省重点研发计划项目(S2021-YF-YBSF-1175)。

摘　　要：目的探讨咳嗽变异性哮喘(CVA)患儿血清脂氧素A4(LXA4)、淀粉样蛋白A(SAA)、嗜酸性细胞阳离子蛋白(ECP)水平预测咳嗽变异性哮喘患儿预后的价值,以期为临床治疗提供参考。方法本研究选取2020年1月—2023年10月在延安市人民医院就诊的114例CVA患儿为观察组;选取同期健康体检82例儿童为对照组。比较2组研究对象LXA4、SAA、ECP水平及呼气峰值流速(PEF)、呼出气一氧化氮(FeNO)。利用Pearson相关分析患儿LXA4、SAA、ECP水平与PEF、FeNO相关性。依据患儿预后将患儿分为预后良好组(n=80)与预后不良组(n=34)。比较2组患儿LXA4、SAA、ECP与PEF、FeNO水平。绘制受试者工作特征(ROC)曲线分析血清LXA4、SAA、ECP水平对患儿预后的预测效能。结果观察组患儿LXA4、SAA、ECP及FeNO水平高于对照组研究对象,PEF低于对照组研究对象,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示:CVA患儿血清LXA4、SAA、ECP水平与PEF呈负相关,与FeNO呈正相关(P<0.05)。预后良好组患儿LXA4、SAA、ECP及FeNO水平均低于预后不良组,PEF高于预后不良组(P<0.05)。绘制LXA4、SAA、ECP水平预测CVA患儿预后的ROC曲线,计算曲线下面积(AUC),结果显示:LXA4、SAA、ECP水平对CVA患儿预后具有较高的预测价值(AUC>0.7)。结论CVA患儿存在血清LXA4、SAA、ECP及FeNO水平增高,PEF下降的现象。血清LXA4、SAA、ECP水平对患儿预后具有较高的预测价值,可评估患儿的疾病严重程度。Objective To explore the predictive value of serum lipoxin A4(LXA4),serum amyloid A(SAA),and eosinophil cationic protein(ECP)levels in the prognosis of children with cough variant asthma(CVA),aiming to provide clinical treatment references.Methods This study selected 114 children with CVA treated at Yan'an People's Hospital between January 2020 and October 2023 as the observation group,and 82 healthy children during the same period as the control group.Levels of LXA4,SAA,ECP,peak expiratory flow(PEF),and fractional exhaled nitric oxide(FeNO)were compared between the two groups.Pearson correlation analysis was used to examine the relationship between LXA4,SAA,ECP levels and PEF,FeNO.Based on prognosis,the children were allocated to a good prognosis subgroup(n=80)and a poor prognosis group(n=34).LXA4,SAA,ECP levels,PEF,and FeNO were compared between these two groups.The predictive efficacy of serum LXA4,SAA,and ECP levels for prognosis was analyzed using ROC curves.Results The observation group had significantly higher levels of LXA4,SAA,ECP,and FeNO,and lower PEF than the control group(P<0.05).Pearson correlation analysis showed that serum LXA4,SAA,and ECP levels in CVA children were negatively correlated with PEF and positively correlated with FeNO(P<0.05).The good prognosis group had significantly lower levels of LXA4,SAA,ECP,and FeNO,and higher PEF compared to the poor prognosis group(P<0.05).The ROC curve analysis indicated that LXA4,SAA,and ECP levels have high predictive value for the prognosis of CVA children(AUC>0.7).Conclusion Children with CVA have elevated levels of serum LXA4,SAA,ECP,and FeNO,and decreased PEF.LXA4,SAA,

关 键 词：咳嗽变异性哮喘 脂氧素A4 淀粉样蛋白A 嗜酸性细胞阳离子蛋白 

分 类 号：R725.6[医药卫生—儿科]