蛋白质翻译后修饰对环磷酸鸟苷-腺苷酸合成酶功能的调控  

Regulation of cyclicGMP-AMP synthase function by protein post-translational modifications

作　　者：申梦阳 路晨 王怡 裴金勇 王洁[1] 杨波[1] SHEN Mengyang;LU Chen;WANG Yi;PEI Jinyong;WANG Jie;YANG Bo(School of Medical Technology,Xinxiang Medical University,Xinxiang 453003,Henan Province,China)

机构地区：[1]新乡医学院医学技术学院,河南新乡453003

出　　处：《新乡医学院学报》2024年第8期701-705,共5页Journal of Xinxiang Medical University

基　　金：国家自然科学基金资助项目(编号:82371759)。

摘　　要：环磷酸鸟苷-腺苷酸合成酶-干扰素基因刺激因子信号通路是细胞感知细胞质中异常存在的双链DNA的主要效应器,对于该信号通路的调节,可以通过调控细胞质内DNA识别受体环磷酸鸟苷-腺苷酸合成酶的功能来完成。近年来研究发现,蛋白质翻译后修饰,包括磷酸化、乙酰化、泛素化、甲基化、类泛素修饰等在固有免疫信号通路的调节中具有重要功能。本文就蛋白质翻译后修饰如何通过不同的机制对环磷酸鸟苷-腺苷酸合成酶的功能及其下游的信号通路产生多种多样的影响进行阐述。The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes signaling pathway plays a central role in cells’ability to sense the presence of abnormal double-stranded DNA within the cytoplasm.Modulation of the function of the cytoplasmic DNA recognition receptor cGAS allows regulation of this signaling pathway.In recent years,research has identified protein post-translational modifications(PTMs),including phosphorylation,acetylation,ubiquitination,methylation,and SUMOylation,as having significant roles in regulating innate immune signaling pathways.This paper reviews how PTMs influence the function of cGAS and its downstream signaling pathways through various mechanisms.

关 键 词：蛋白质翻译后修饰 环磷酸鸟苷-腺苷合成酶 信号转导 固有免疫 

分 类 号：R392[医药卫生—免疫学]