PⅠNP在儿童生长发育中的应用价值  

Application value of PIMP in child growth and development

作　　者：赵晓鑫 蔡艾媛 梁雅雯 李彦昕[4] ZHAO Xiaoxin;CAI Aiyuan;LIANG Yawen;LI Yanxin(The Second Clinical Medical School,Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510405,China;Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou,Guangdong 510120,China;Department of Pediatrics,Affiliated Fifth Hospital of Guangzhou Medical University,Guangzhou,Guangdong 510799,China;LUO Xiaorong Famous Doctor Studio,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou,Guangdong 510120,China)

机构地区：[1]广州中医药大学第二临床医学院,广州510405 [2]广东省中医院儿科,广州510120 [3]广州医科大学附属第五医院儿科,广州510799 [4]广东省中医院罗笑容名医工作室,广州510120

出　　处：《重庆医学》2024年第15期2313-2318,共6页Chongqing Medical Journal

基　　金：国家中医药管理局罗笑容全国名老中医药专家传承工作室建设项目(14GG2X02)。

摘　　要：目的探讨Ⅰ型原胶原N肽前端(PⅠNP)在儿童生长发育中的应用价值。方法回顾性分析2023年3-8月广东省中医院儿科就诊的99例儿童临床资料,包括性别、年龄、身高、体重、BMI、就诊季节、Tanner分期,PⅠNP、β-胶原降解产物(β-CTx)、N端骨钙素(N-MID),分析不同性别、PⅠNP水平的儿童一般资料,以及PⅠNP与生长速率的偏相关性,再通过受试者工作特征(ROC)曲线分析PⅠNP预测儿童生长速率缓慢的效能。结果不同PINP水平的儿童身高标准差、Tanner分期、β-CTx、N-MID、抽血后身高、抽血后生长速率、生长速率缓慢比较,差异有统计学意义(P<0.05)。偏相关分析中,PⅠNP与β-CTx(r=0.671)、NMID(r=0.506)、抽血前生长速率(r=0.551)、抽血后生长速率(r=0.474)存在相关性(P<0.05);线性回归中,PⅠNP与儿童身高生长速率呈线性正相关,随着PⅠNP数值越大,儿童过去或未来3个月的身高生长速率可能越高(P<0.05)。ROC曲线结果显示,当PⅠNP<434.8 ng/mL时,儿童身高生长速率存在缓慢的风险(AUC为0.819,95%CI:0.712~0.927,灵敏度为80.0%,特异度为78.6%)。结论PⅠNP水平可反映儿童日常生活中过去或未来3个月的身高生长速率,对儿童生长速率缓慢有一定预测价值。Objective To investigate the application value of typeⅠprocollagen N-peptide front-end(PⅠNP)in growth and development in children.Methods The clinical data of 99 children visiting in the pediatric department of Guangdong Provincial Hospital of Traditional Chinese Medicine from March to August 2023 were analyzed retrospectively,including gender,age,height,weight,BMI,visiting season,Tanner stage,PⅠNP,β-collagen degradation product(β-CTx),N-terminal osteocalcin(N-MID).The general data of children with different sex and PⅠNP level were analyzed.The partial correlation between PⅠNP and growth rate was analyzed.Then the efficiency of PⅠNP for predicting the child growth rate slow was conducted by the receiver operating characteristic(ROC)curve.Results The children height standard deviation,Tanner stage,β-CTx,N-MID,height after blood drawing,growth rate after blood drawing,growth rate slowness had statistical difference among the children with different PⅠNP levels(P<0.05).In the partial correlation,PⅠNP has the correlation withβ-CTx(r=0.671),N-MID(r=0.506),growth rate before blood drawing(r=0.551)and growth rate after blood drawing(r=0.474,P<0.05).In linear regression,PⅠNP was linearly correlated with children’s height growth rate,and the greater the PⅠNP value was,the higher the children’s height growth rate in the past or the next three months was likely to be(P<0.05).The ROC curve results showed that when PⅠNP<434.8 ng/mL,there was a risk of slow height growth rate in children(AUC was 0.819,95%CI:0.712-0.927,sensitivity was 80.0%,specificity was 78.6%).Conclusion The PⅠNP level could reflect the height growth rate of children in the past or the next three months in their daily life,and has certain predictive value for the slow growth rate of children.

关 键 词：儿童 生长发育 骨代谢标志物 Ⅰ型原胶原N肽前端 预测 

分 类 号：R729[医药卫生—儿科]