肿瘤坏死因子受体2在银屑病中的研究进展  

Research progress on tumor necrosis factor receptor 2 in psoriasis

作　　者：莫念 张雅婷 张骏鸿 汪晴 周攀宇 韩凌 卢传坚[1,2,3,4] MO Nian;ZHANG Yating;ZHANG Junhong;WANG Qing;ZHOU Panyu;HAN Ling;LU Chuanjian(Second Clinical College of Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510006,China;State Key Laboratory of Moisture Syndrome of TCM,Guangzhou,Guangdong 510145,China;Guangdong-Hong Kong-Macao Joint Laboratory of TCM and Immune Disease Research,Guangzhou,Guangdong 510006,China;Guangdong Provincial Hospital of Chinese Medicine,Guangzhou,Guangdong 510120,China)

机构地区：[1]广州中医药大学第二临床医学院,广州510006 [2]省部共建中医湿证国家重点实验室,广州510145 [3]粤港澳中医药与免疫疾病研究联合实验室,广州510006 [4]广东省中医院皮肤科,广州510120

出　　处：《重庆医学》2024年第15期2370-2375,共6页Chongqing Medical Journal

基　　金：广东省科技计划项目(2020B1111100006,2020B1212030006);广东省自然科学基金项目(2020A1515010607);广东省广州市科技计划项目(202201020332);省部共建中医湿证国家重点实验室重点项目(SZ2021ZZ29);广东省中医药科学院专项基金项目(YN2018RBA02);广东省中医院拔尖人才科研专项(BJ2022KY05)。

摘　　要：银屑病主要是由免疫介导、遗传与环境共同作用的难治性疾病。肿瘤坏死因子-α(TNF-α)相关生物制剂为银屑病治疗带来里程碑式进步,然而,抗TNF-α疗法存在不良答应,其局限性可能与TNF-α不同受体激活后发挥的生物学功能不同有关。肿瘤坏死因子受体2(TNFR2)是TNF-α的关键受体之一,在与TNF-α结合后,可激活核因子-κB(NF-κB)、磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)、丝裂原活化蛋白激酶(MAPK)、转录激活子3(STAT3)等多个信号通路,参与炎症、表皮稳态、细胞凋亡、细胞增殖、细胞自噬等生物学过程的调控,提示TNFR2与银屑病的发生、发展关系密切。既往研究往往忽视TNFR2在抗TNF-α疗法中的作用,因此,该文综述了TNFR2的结构、信号转导通路、在疾病中的研究进展及其与银屑病的关系,为探索银屑病的发病机制和治疗提供新的参考。Psoriasis is a refractory disease mainly co-acted by immune,genetic and environment.Tumor necrosis factorα(TNF-α)-related biologics have brought the landmark advances in the treatment of psoriasis;however,the anti-TNF-αtherapy has the adverse response,its limitation may be related to the different biological functions exerted by activation of TNF-αdifferent receptors.Tumor necrosis factor receptor 2(TNFR2)is one of the key receptors for TNF-α,and after binding to TNF-α,it can activate multiple signaling pathways such as NF-κB,PI3K/Akt,MAPK,STAT3,etc.,which are involved in the regulation of inflammation,epidermal homeostasis,cellular apoptosis,cellular proliferation,cellular autophagy and other biological processes.It is suggested that TNFR2 is closely related to the occurrence and development of psoriasis.Previous studies have often overlooked the role of TNFR2 in anti-TNF-αtherapies;therefore,this article reviews the structure and signaling pathways of TNFR2,research advances in the disease,and its relationship with psoriasis to provide new references for exploring the pathogenesis and treatment of psoriasis.

关 键 词：银屑病 肿瘤坏死因子 肿瘤坏死因子受体2 银屑病治疗 综述 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]