清热养阴解毒方治疗肺热壅盛型放射性肺损伤的临床效果  

Clinical effect of Qingre Yangyin Jiedu Prescription in the treatment of radiation-induced lung toxicity with exuberance of lung heat type

作　　者：陆冬云 朱林 章震 杨帆 LU Dongyun;ZHU Lin;ZHANG Zhen;YANG Fan(Department of Oncology,Haian Hospital of Traditional Chinese Medicine,Jiangsu Province,Haian 226600,China)

机构地区：[1]江苏省海安市中医院肿瘤科,江苏海安226600

出　　处：《中国医药导报》2024年第17期17-20,共4页China Medical Herald

基　　金：江苏省自然科学基金面上项目(BK201903021);江苏省南通市基础科学研究和社会民生科技计划项目(MSZ2022104)。

摘　　要：目的 探究清热养阴解毒方治疗肺热壅盛型放射性肺损伤(RILT)的临床效果。方法 选取2021年1月至2023年1月江苏省海安市中医院收治的89例肺热壅盛型RILT患者,根据随机数字表法分为两组,对照组45例,观察组44例。对照组给予激素治疗,静脉推注地塞米松磷酸钠注射液(5 mg/d),观察组在激素治疗的基础上服用清热养阴解毒方。连续服用15 d后评估患者临床效果及中医症状评分,检测患者血清炎症因子、肺功能指标及药物不良反应。结果 观察组疗效优于对照组,差异有统计学意义(P<0.05)。治疗前,两组中医证候主症、次症及总评分比较,差异无统计学意义(P>0.05);治疗后,两组中医证候主症、次症及总评分较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组用力肺活量、第1秒用力呼吸容积/用力肺活量水平比较,差异无统计学意义(P>0.05);治疗后,两组用力肺活量、第1秒用力呼吸容积/用力肺活量水平较治疗前升高,且观察组高于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 清热养阴解毒方能够提高肺热壅盛型RILT患者的临床疗效,改善患者中医症状,提高肺功能。Objective To investigate the clinical effect of Qingre Yangyin Jiedu Prescription in the treatment of radiation-induced lung toxicity(RILT)with exuberance of lung heat type.Methods Eighty-nine RILT patients with exuberance of lung heat type admitted to Haian Hospital of Traditional Chinese Medicine,Jiangsu Province from January 2021 to January 2023 were selected and they were divided into two groups according to random number table method,45 patients in the control group and 44 patients in the observation group.The control group was given hormone therapy,intravenous injection of Dexamethasone Sodium Phosphate Injection(5 mg/d),the observation group was given QingreYangyin Jiedu Prescription on the basis of hormone therapy.After continuous administration for 15 days,the clinical effect and traditional Chinese medicine symptom score of the patients were evaluated,and serum inflammatory factors,pulmonary function indexes,and adverse drug reactions were detected.Results The curative effect of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the main syndrome,secondary syndrome,and total score of traditional Chinese medicine syndrome between the two groups(P>0.05).After treatment,the main syndrome,secondary syndrome,and total score of traditional Chinese medicine syndrome in the two groups were lower than before treatment,and those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in forced vital capacity and forced expiratory volume in one second/forced vital capacity between the two groups(P>0.05).After treatment,forced vital capacity and forced expiratory volume in one second/forced vital capacity of the two groups were higher than before treatment,and those of the observation group were higher than those of the control group,and the differences were statistical

关 键 词：清热养阴解毒法 放射性肺损伤 肺热壅盛 激素 

分 类 号：R273[医药卫生—中西医结合]