血清超氧化物歧化酶、一氧化氮、内皮素1在妊娠高血压综合征中的临床应用价值  

Clinical application value of serum superoxide dismutase,nitric oxide,and endothelin-1 in pregnancy-induced hypertension syndrome

作　　者：王国镇[1] 荣春红[2] 郑静 张铁[1] WANG Guozhen;RONG Chunhong;ZHENG Jing;ZHANG Tie(Department of Clinical Laboratory,China-Japan Friendship Hospital,Beijing100029,China;Department of Gynecology and Obstetrics,China-Japan Friendship Hospital,Beijing100029,China)

机构地区：[1]中日友好医院检验科,北京100029 [2]中日友好医院妇产科,北京100029

出　　处：《中国医药导报》2024年第18期88-91,共4页China Medical Herald

基　　金：北京市朝阳区科技计划课题(CYSF2224,CYSF1930)。

摘　　要：目的探索超氧化物歧化酶(SOD)、一氧化氮(NO)、内皮素1(ET-1)在妊娠高血压综合征患者血清中的临床应用价值。方法选择2022年9月至2023年9月在中日友好医院妇产科就诊并确诊为妊娠高血压综合征的孕妇110例为妊高征组,根据高血压的分级标准分为轻度妊高征组80例和重度妊高征组30例,同时选取90名健康孕妇为对照组。使用全自动生化仪检测上述三组孕产妇的SOD、NO及常规生化及血脂指标,采用酶联免疫吸附试验检测上述两组孕产妇ET-1水平,采用SPSS19.0统计学软件对受试者的检测结果进行统计分析,进一步采用多因素logistic回归模型分析妊高征的影响因素。结果妊高征组ET-1、总胆固醇、甘油三酯、低密度脂蛋白均高于对照组,而SOD、NO、HDL低于对照组,差异有统计学意义(P<0.05);轻度妊高征组、重度妊高征组SOD、NO水平低于对照组,ET-1水平高于对照组,差异有统计学意义(P<0.05);重度高血压组血清SOD、NO水平低于轻度妊高征组,ET-1水平高于轻度妊高征组,差异有统计学意义(P<0.05);logistic回归分析结果显示:血清SOD、NO、ET-1、HDL均为孕妇发生妊高征的独立影响因素。结论SOD、NO、ET-1作为妊娠高血压疾病的血清学生物标志物具有良好的临床应用价值。Objective Clinical application value of serum superoxide dismutase(SOD),nitric oxide(NO),and endothelin-1(ET-1)in pregnancy hypertension disease.Methods One hundred and ten pregnant women who attended the Department of Obstetrics and Gynaecology of China-Japan Friendship Hospital from September 2022 to September 2023 and were diagnosed with hypertensive syndrome in pregnancy were selected as the hyperemesis group.According to the grading criteria of hypertension,they were divided into 80 cases in the mild hyperemesis group and 30 cases in the severe hyperemesis group,while 90 healthy pregnant women were selected as the control group.SOD,NO and routine biochemical and lipid indices of the above three groups of mothers were measured by fully automated biochemistry.Enzyme-linked immunosorbent assay was used to detect maternal ET-1 levels in the above two groups,SPSS19.0 statistical software was used to analyze the test results of the subjects,and multivariate logistic regression model was used to analyze the influencing factors of PIH.Results ET-1,total cholesterol,triglyceride and low density lipoprotein in PIH group were higher than those in control group,while SOD,NO and HDL were lower than those in control group,the difference was statistically significant(P<0.05).SOD and NO levels in mild PIH group and severe PIH group were lower than those in control group,and ET-1 levels were higher than those in control group,the difference was statistically significant(P<0.05),Serum SOD and NO levels in severe hypertension group were lower than those in mild PIH group,and ET-1 levels were higher than those in mild PIH group,the difference was statistically significant(P<0.05).logistic regression analysis showed that serum SOD,NO,ET-1 and HDL were independent factors influencing the occurrence of PIH.Conclusion SOD,NO and ET-1 have good clinical application value as serological biomarkers of hypertensive diseases in pregnancy.

关 键 词：妊娠高血压疾病 超氧化物歧化酶 一氧化氮 内皮素 

分 类 号：R71[医药卫生—妇产科学]