星状神经节阻滞联合复方甲氧那明胶囊治疗感染后咳嗽的临床效果  

Clinical effect of stellate ganglion block combined with Compound Met-hoxyamine Capsules in the treatment of post-infectious cough

作　　者：李佳英 翟瑞瑞 赵亚杰 周脉涛 LI Jiaying;ZHAI Ruirui;ZHAO Yajie;ZHOU Maitao(School of Anesthesiology,Xuzhou Medical University,Jiangsu Province,Xuzhou221004,China)

机构地区：[1]徐州医科大学麻醉学院,江苏徐州221004

出　　处：《中国医药导报》2024年第19期13-17,共5页China Medical Herald

基　　金：江苏省科技项目(BE2018669);江苏省无锡市卫生健康委科普作品创作项目(P202108)。

摘　　要：目的探讨星状神经节阻滞(SGB)联合复方甲氧那明胶囊治疗感染后咳嗽(PIC)的临床效果及安全性。方法选取2023年2月至2024年2月中国人民解放军联勤保障部队第九〇四医院收治的PIC患者117例,采用随机数字表法将其分为对照组(59例)和观察组(58例)。对照组给予复方甲氧那明胶囊口服,观察组给予复方甲氧那明胶囊口服联合SGB。两组均连续治疗10 d。比较两组临床疗效,治疗前后痰量积分、咳嗽积分、血清P物质(SP)、白细胞介素-8(IL-8)、C反应蛋白(CRP)水平及治疗期间不良反应的发生情况。结果治疗后,两组痰量积分与咳嗽积分较治疗前降低,且观察组低于对照组(P<0.05)。观察组临床疗效优于对照组(P<0.05)。治疗后,两组SP、IL-8、CRP水平较治疗前降低,且观察组低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论SGB联合复方甲氧那明胶囊治疗PIC有明显的临床效果且安全,无明显不良反应。Objective To investigate the clinical effict and safety of stellate ganglion block(SGB)combined with Compound Methoxyamine Capsules in the treatment of post-infectious cough(PIC).Methods A total of 117 patients with PIC admitted to No.904 Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army from February 2023 to February 2024 were divided into control group(59 cases)and observation group(58cases)by random number table method.The control group was given Compound Methoxyamine Capsules orally,and the observation group was given Compound Methoxyamine Capsules orally combined with SGB.Both groups were treated continuously for ten days.The clinical efficacy,sputum volume score,cough score,serum Substance P(SP),interleukin-8(IL-8),C-reactive protein(CRP)levels before and after treatment and the occurrence of adverse reactions during treatment were compared between the two groups.Results After treatment,the sputum volume score and cough score of the two groups were lower than before treatment,and those in the observation group werelower than those in the control group(P<0.05).The clinical effect of the observation group was better than that of the control group(P<0.05).After treatment,the levels of SP,IL-8,and CRP in both groups were lower than before treatment,and those in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion SGB combined with Compound Methoxyamine Capsules has obvious clinical efficacy and safety in the treatment of PIC,without obvious adverse reactions.

关 键 词：星状神经节阻滞 复方甲氧那明胶囊 感染后咳嗽 

分 类 号：R459.9[医药卫生—治疗学]