用于伤口敷料的水凝胶电刺激释药性能  

Hydrogel-based drug releasing system with external electricity stimulation for wound dressing

作　　者：贾娟 杨扬[1] 朱恂[1] 叶丁丁[1] 陈蓉[1] 廖强[1] JIA Juan;YANG Yang;ZHU Xun;YE Dingding;CHEN Rong;LIAO Qiang(College of Energy and Power Engineering,Chongqing University,Chongqing 400044,China)

机构地区：[1]重庆大学能源与动力工程学院,重庆400044

出　　处：《化工学报》2024年第7期2700-2708,共9页CIESC Journal

基　　金：国家自然科学基金优秀青年科学基金项目(52322604);国家自然科学基金创新研究群体项目(52021004);陕西省自然科学基础研究计划项目(2019JQ-629)。

摘　　要：水凝胶是一种具有三维空间网络结构的高分子材料,可以作为理想的新型伤口敷料,但在自然释放条件下水凝胶伤口敷料释药速率缓慢。为了促进伤口愈合,以羧甲基壳聚糖和海藻酸钠为基体,在水凝胶中加入了导电剂聚吡咯和抗菌药物盐酸环丙沙星,制备了载药水凝胶,构筑了水凝胶电刺激释药装置。研究了不同聚吡咯含量下水凝胶的溶胀性能、力学性能和导电性能的变化,以及在电刺激条件下盐酸环丙沙星药物释放规律。研究表明:聚吡咯与基体投料比为0.4时,水凝胶在理化性能和力学性能上综合表现最佳,更适合用于伤口敷料。电刺激作用可以有效加速水凝胶内部的药物释放,对于伤口的治疗具有积极的意义。Hydrogel is a polymer material with a three-dimensional network structure and can be used as an ideal new wound dressing.However,the releasing rate of hydrogel wound dressing is slow under natural conditions.To promote wound healing,the hydrogel is prepared by using carboxymethyl chitosan and sodium alginate as matrix,and polypyrrole as the conductive agent.The ciprofloxacin hydrochloride is added into the hydrogel as the antibacterial drug.The drug releasing device driven by the electrostimulation is constructed.The impacts of polypyrrole content on the swelling property,mechanical property and electrical conductivity,and the releasing property of ciprofloxacin hydrochloride under electrical stimulation are studied.When the ratio of polypyrrole to the matrix is 0.4,the hydrogel shows the optimized comprehensive performance in physicochemical property and mechanical property,and is more suitable for wound dressing.The electrical stimulation can effectively accelerate the releasing rate of drugs interior the hydrogel,and benefit the treatment of wounds.

关 键 词：羧甲基壳聚糖 水凝胶 伤口敷料 药物 扩散 凝胶 

分 类 号：R313[医药卫生—基础医学]