晕动病临床模型及基于血液指标诊断模型的构建  

Construction of motion sickness clinical model and diagnosis model based on blood index

作　　者：谢奇伟 屠佳丽 王耀文 章伟敏 史候 王燕[1] 朱华麟 XIE Qiwei;TU Jiali;WANG Yaowen;ZHANG Weimin;SHI Hou;WANG Yan;ZHU Hualin(Department of Otolaryngology Head and Neck Surgery,the First Affiliated Hospital of Ningbo University,Ningbo,Zhejiang,315000,China)

机构地区：[1]宁波大学附属第一医院耳鼻咽喉头颈外科,浙江宁波315000

出　　处：《中国耳鼻咽喉头颈外科》2024年第7期435-439,共5页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金：浙江省中医药科技计划项目(2023ZL648);吴阶平医学基金会临床科研专项(320.6750.2020-08-31);浙江省医药科技计划项目(2019PY069)。

摘　　要：目的构建晕动病临床模型,为晕动病研究提供相对客观的诊断模型,并为该病的进一步临床干预提供依据。方法共纳入受试者60例,依据有无晕动病分为实验组及对照组。使用SRM-IV旋转椅建立晕动病临床模型。采集其加速度暴露前、后外周血,检测外周血促肾上腺皮质激素(adrenocorticotropic hormone,ACTH),生长激素(growth hormone,GH),催乳素(prolactin,PRL),卵泡刺激素(follicle stimulating hormone,FSH),黄体生成素(luteinizing hormone,LH),促甲状腺激素(thyrotropin,TRH),胃泌素-17(gastrins-17,G-17),乙酰胆碱(acetylcholine,ACH),5-羟色胺(5-hydroxytryptamine,5-HT)含量,使用Graybiel量表评价晕动病严重程度。通过多元线性回归分析晕动病症状体征与外周血指标的相关性,建立诊断模型。结果加速度暴露后实验组外周血Graybiel评分、ACH、5-HT、ACTH、GH、PRL含量较暴露前升高,且与对照组差异显著(P<0.001)。FSH、LH、TRH、G-17在加速度暴露前、后及两组之间均无明显差异(P>0.05)。多指标联合诊断模型:Graybiel评分=-9.32+0.131×ACTH+0.055×ACH+0.041×5-HT。结论晕动病发作时ACH、5-HT、ACTH、GH、PRL含量升高,多指标联合诊断模型可以为临床上晕动病的客观诊断提供一定的依据。OBJECTIVE To construct a clinical model of motion sickness(MS),provide a relatively objective diagnostic model for MS research,and provide a basis for further clinical intervention of the disease.METHODS A total of 60 subjects were included and divided into experimental group and control group according to the presence or absence of MS.The MS clinical model was established using SRM-IV rotating chair.Peripheral blood was collected before and after acceleration exposure,and the contents of adrenocorticotropic hormone(ACTH),growth hormone(GH),prolactin(PRL),follicle stimulating hormone(FSH),luteinizing hormone(LH),thyroid stimulating hormone(TRH)and gastrin-17(G-17),acetylcholine(ACH)and 5-hydroxytryptamine(5-HT)were detected,Graybiel scale was used to evaluate the severity of MS.The correlation between MS symptoms and signs and peripheral blood indexes was analyzed by multiple linear regression,and the diagnostic model was established.construct a clinical model of MS and a diagnostic model based on blood parameters,so as to provide a reliable clinical model and an objective diagnostic model for MS research,and to provide a basis for further clinical intervention of the disease.RESULTS After acceleration exposure,the Graybiel scores,ACH,5-HT,ACTH,GH and PRL levels in peripheral blood of the experimental group were higher than those before exposure,and were significantly different from those of the control group(P<0.001).There was no significant difference in FSH,LH,TRH and G-17 between the two groups before and after acceleration exposure(P>0.05).Multi-index combined diagnostic model:Graybiel scores=-9.32+0.131×ACTH+0.055×ACH+0.041×5-HT.CONCLUSION The levels of ACH,5-HT,ACTH,GH and PRL increased during the onset of MS.The multi-index combined diagnosis model can provide a certain basis for the objective diagnosis of MS in clinical practice.

关 键 词：晕动病 垂体激素类 乙酰胆碱 胃泌素类 5-羟色胺 临床模型 

分 类 号：R594.6[医药卫生—内科学]