基于“郁、虚、毒”理论探讨抑郁促癌发病机制  

Exploration on the Pathogenesis of Depression Promoting Cancer Based on the Theory of“Depression,Deficiency,and Toxin”

作　　者：陈可莹 李娜 唐莹[1,3] 刘乃华 喻芳君 方邦江 史亚飞[2] CHEN Ke-ying;LI Na;TANG Ying;LIU Nai-hua;YU Fang-jun;FANG Bang-jiang;SHI Ya-fei(Science and Technology Innovation Center,Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;School of Fundamental Medical Science,Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China;Institute of TCM Oncology of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;School of Pharmaceutical Sciences,Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China;Longhua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]广州中医药大学科技创新中心,广东广州510405 [2]广州中医药大学基础医学院,广东广州510006 [3]广州中医药大学中医肿瘤研究所,广东广州510405 [4]广州中医药大学中药学院,广东广州510006 [5]上海中医药大学附属龙华医院,上海200032

出　　处：《中医肿瘤学杂志》2024年第4期29-33,共5页Journal of Oncology in Chinese Medicine

基　　金：国家自然科学基金项目(编号:82205220、82305169);广东省自然科学基金面上项目(编号:2024A1515012172、2023A1515010751);中国博士后科学基金第37批面上资助项目(编号:2023M730811)。

摘　　要：随着社会生活方式的快速改变,情志异常与恶性肿瘤之间的相互作用日益突显。大量研究表明,以抑郁为主要改变的情志异常可以通过多种途径影响肿瘤的发生发展与转移。“抑郁情伤促癌”机制越来越受到人们的重视。现今迫切需要发现抑郁症与肿瘤之间的创新因果关系和机制,并开发有效的治疗方法。肝气郁结是情志致病的始动因素,正气亏虚是肿瘤发生的内在基础,癌毒侵袭是肿瘤滋生转移的重要病理环节,综合以上三者可初步表明,“郁、虚、毒”是抑郁促肿瘤发生发展的核心病因病机。以“抑郁情伤促癌”为问题导向,探讨其郁、虚、毒的病机内涵及其致病机制和有效干预方法,可以为抑郁促肿瘤发生发展的防治研究提供新的思路和方向。With the rapid change of social lifestyle,the interaction between emotional abnormality and malignant tumor has become increasingly prominent.A large number of studies have shown that emotional abnormality,with depression as the main change,can affect the occurrence,development,and metastasis of tumor through multiple pathways.The mechanism of“depression promoting cancer”has attracted more and more attention.Nowadays there is an urgent need to discover innovative causal relationship and mechanism between depression and tumor,and to develop effective treatment.Stagnation of liver qi is the initiating factor of emotional disease,and deficiency of healthy qi is the intrinsic basis of tumor occurrence.The invasion of cancer toxin is an important pathological link in the growth and metastasis of tumor.Based on the above three factors,it can be preliminarily shown that“depression,deficiency,and toxin”are the core etiologies and pathogeneses of depression promoting the occurrence and development of tumor.Taking“depression promoting cancer”as a problem-oriented approach,exploring the pathogenesis connotation of depression,deficiency,and toxin,as well as its pathogenic mechanism and effective intervention method can provide new ideas and directions for the prevention and treatment research of depression promoting the occurrence and development of tumor.

关 键 词：抑郁促癌 肿瘤 郁 虚 毒 

分 类 号：R273[医药卫生—中西医结合] R277.7[医药卫生—中医肿瘤科]