基于运动训练的呼吸康复治疗尘肺病患者疗效meta分析  

Meta-analysis on the effects of exercise training-based respiratory rehabilitation therapy in pneumoconiosis patients

作　　者：葛建文 薛婷 李志敏 马星星 董彦[2] 戴文娟 李冬艳[2] GE Jianwen;XUE Ting;LI Zhimin;MA Xingxing;DONG Yan;DAI Wenjuan;LI Dongyan(Academy of Medical Sciences,Shanxi Medical University,Taiyuan,Shanxi 030001,China;不详)

机构地区：[1]山西医科大学医学科学院,山西太原030001 [2]国家卫生健康委尘肺病重点实验室,呼吸疾病防治与基础研究,山西省重点实验室,山西医科大学第一医院呼吸与危重症医学科,山西太原030001

出　　处：《中国职业医学》2024年第3期285-291,共7页China Occupational Medicine

基　　金：中央级公益性科研院所科研业务项目(2020-PT320-005);山西省自然科学基金基础研究计划项目(201901D111354,20210302124039);山西省高等学校科技创新项目(2020L0201)。

摘　　要：目的综合分析基于运动训练的呼吸康复治疗对职业性尘肺病(以下简称“尘肺病”)患者的疗效。方法采用文献计量学法,以中国期刊全文数据库、万方数据知识服务平台、维普数据库和中国生物医学文献服务系统为数据源,检索建库以来至2023年7月发表的基于运动训练的呼吸康复治疗尘肺病患者的随机对照试验文献。采用RevMan 5.4软件对入选文献进行meta分析,采用亚组分析探讨研究异质性来源,采用漏斗图法检验研究发表偏倚。结果共纳入55篇文献,涉及试验组患者2436例,对照组患者2405例。随机或固定效应模型显示,与常规治疗比较,呼吸康复治疗后患者的6 min步行距离、《健康调查简表36项》总分、用力肺活量(FVC)、第一秒用力肺活量(FEV_(1))、FEV_(1)/FVC和动脉血氧分压(PaO2)均升高(P值均<0.05),《圣乔治呼吸问卷》总分和动脉血二氧化碳分压均降低(P值均<0.05)。亚组分析结果显示,康复治疗时间≥6个月患者的《圣乔治呼吸问卷》总分、FEV_(1)和PaO2改善程度均优于<6个月者(P值均<0.01)。所纳入文献未见明显发表偏倚。结论基于运动训练的呼吸康复治疗可改善尘肺病患者的生活质量、运动耐力、呼吸功能和动脉血气。Objective To comprehensively analyze the effectiveness of exercise training-based respiratory rehabilitation therapy on patients with occupational pneumoconiosis(hereinafter referred to as"pneumoconiosis").Methods Literature on randomized controlled trials of exercise training-based respiratory rehabilitation therapy for pneumoconiosis patients published from the establishment of the database to July 2023 was retrieved from academic systems such as the China National Knowledge Infrastructure,Wanfang Data Knowledge Service Platform,VIP Database,and China Biology Medicine using bibliometrics method.The RevMan 5.4 software was used for meta-analysis of the selected literatures.Subgroup analysis was conducted to explore the source of study heterogeneity.The funnel plot method was used to test publication bias.Results A total of 55 articles were included,involving 2436 pneumoconiosis patients in the experimental group and 2405 pneumoconiosis patients in the control group.The result of random or fixed effect model showed that the six minutes walking distance,the total score of Short from Health Survey-36,forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1)),FEV_(1)/FVC,arterial partial pressure of oxygen of pneumoconiosis patients increased after respiratory rehabilitation therapy(all P<0.05),while the total score of the St.George′s Respiratory Questionnaire and arterial partial pressure of carbon dioxide decreased compared with the conventional treatment(all P<0.05).The result of subgroup analysis showed that the total score of the St.George′s Respiratory Questionnaire,FEV_(1),and the index of arterial partial pressure of oxygen of pneumoconiosis patients was better in the rehabilitation treatment for≥six months compared with those<six months(all P<0.01).The funnel plot result showed that no obvious publication bias.Conclusion Exercise training-based respiratory rehabilitation therapy can improve the quality of life,exercise endurance,respiratory function,and arterial blood gas levels of pat

关 键 词：运动 训练 康复 尘肺病 META分析 生活质量 呼吸功能 

分 类 号：R135.2[医药卫生—劳动卫生]