碲锌镉心脏专用SPECT心肌灌注显像及其血流定量测定在冠心病诊断中的临床应用和研究进展  

Clinical application and research progress of myocardial perfusion imaging and its quantification of blood flow with cadmium-zinc-telluride dedicated cardiac SPECT in patients with coronary artery disease

作　　者：刘颖菲 李剑明[1] Liu Yingfei;Li Jianming(Clinical School of Cardiovascular Disease,Tianjin Medical University,Department of Nuclear Medicine,TEDA International Cardiovascular Hospital,Tianjin 300457,China)

机构地区：[1]天津医科大学心血管病临床学院,泰达国际心血管病医院核医学科,天津300457

出　　处：《国际放射医学核医学杂志》2024年第6期386-392,共7页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：天津市医学重点学科(专科)建设项目(TJYXZDXK-020A);泰达国际心血管病医院课题(2021-TD-003)。

摘　　要：冠心病(CAD)是严重威胁人类健康的重大疾病之一。SPECT心肌灌注显像(MPI)能对CAD进行无创性诊断、危险分层和判断预后。随着配备新一代常温固体半导体碲锌镉(CZT)探测器的心脏专用SPECT的临床推广应用,SPECT MPI不仅在采集时间、辐射剂量和图像质量等方面得到了明显改善和提升,而且较方便地实现了动态断层采集和定量心肌血流的测量,对CAD准确诊断和预后评估具有十分重要的增益价值。笔者旨在从CZT心脏专用SPECT MPI及其血流定量测定在CAD诊断中的临床应用和研究进展进行综述。Coronary artery disease(CAD)is one of the major diseases that seriously threaten human health.SPECT myocardial perfusion imaging(MPI)is able to diagnose CAD noninvasively,stratify the risk and determine the prognosis.With the clinical application of a new generation of dedicated cardiac SPECT equipped with cadmium zinc telluride(CZT)detector,not only the acquisition time,radiation dose,and image quality of SPECT MPI have been significantly improved and enhanced,but also the dynamic tomographic acquisition and quantitative myocardial blood flow measurement have been realized more conveniently,which has a very important incremental value for the accurate diagnosis and prognosis evaluation of CAD.The authors review the clinical application and research progress of CZT dedicated cardiac SPECT MPI and its quantitative blood flow measurement for CAD.

关 键 词：冠状动脉疾病 碲锌镉 体层摄影术 发射型计算机 单光子 体层摄影术 X线计算机 心肌灌注显像 

分 类 号：R541.4[医药卫生—心血管疾病]