基于超极速脉搏波技术定量评估高血压患者颈动脉脉搏波速度指数的影响因素  

The influencing factors of carotid pulse wave velocity index in patients with hypertension by ultrafast pulse wave technique

作　　者：季雯晶 朱正球[1] 张颖[1] 吴林琳 刘福明[2] 邹冲[3] 黄辉[1] Ji Wenjing;Zhu Zhengqiu;Zhang Ying;Wu Linlin;Liu Fuming;Zou Chong;Huang Hui(Department of Ultrasound,Jiangsu Provincial Hospital of Traditional Chinese Medicine,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210029,Jiangsu,China;Department of Cardiology,Jiangsu Provincial Hospital of Traditional Chinese Medicine,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210029,Jiangsu,China;Department of GCP Center,Jiangsu Provincial Hospital of Traditional Chinese Medicine,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210029,Jiangsu,China)

机构地区：[1]江苏省中医院南京中医药大学附属医院超声医学科,江苏南京210029 [2]江苏省中医院南京中医药大学附属医院心内科,江苏南京210029 [3]江苏省中医院南京中医药大学附属医院GCP中心,江苏南京210029

出　　处：《血管与腔内血管外科杂志》2024年第6期672-676,共5页Journal of Vascular and Endovascular Surgery

基　　金：江苏省第十六批“六大人才高峰”创新人才团队项目(TD-SWYY-069);江苏省中医药管理局中医药科技发展计划重点项目(ZD201906);江苏省卫生健康委员会老年健康科研项目(LK2021005)。

摘　　要：目的基于超极速脉搏波(ufPWV)技术定量评估高血压患者颈动脉脉搏波速度指数(PWVI)的影响因素。方法选择2018年1月至2022年8月于江苏省中医院南京中医药大学附属医院行ufPWV检测的健康成年人121名为建模组,另招募208例高血压患者为试验组。收集所有受试者的一般资料、体格检查、实验室检查与ufPWV影像学检查结果,建模组利用多元逐步线性回归分析得出理论的弹性指标方程,然后利用该方程计算PWVI进一步分析各动脉粥样硬化危险因素对PWVI的影响。结果根据建模组得出理论的弹性方程为收缩终末脉搏波速度(PWVES)(m/s)=0.083×年龄(岁)+0.036×平均动脉压(mmHg)+0.681×性别(女=0,男=1)+0.164,据此将试验组分为弹性衰退组(n=115,PWVI≥0)及弹性正常组(n=93,PWVI﹤0),两组患者性别、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖、吸烟史比较,差异均有统计学意义(P﹤0.05),PWVI的增加与TC(r=0.251,P=0.006)、LDL(r=0.401,P﹤0.01)水平呈显著正相关,与HDL(r=-0.247,P﹤0.01)水平呈显著负相关。结论基于ufPWV技术检测动脉弹性指标PWV-ES及其计算所得的PWVI可以作为评估高血压患者动脉粥样硬化弹性衰退进展的无创且可靠的评估手段。Objective Quantitative evaluation of the influencing factors of carotid pulse wave index(PWVI)in hypertensive patients based on ultra fast pulse wave(ufPWV)technology.Method A total of 121 healthy adults who underwent ufPWV detection in the Jiangsu Provincial Hospital of Traditional Chinese Medicine,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine from January 2018 to August 2022 were selected as the modeling group,and another 208 patients with hypertension were recruited as the experimental group.The results of general data,physical examination,laboratory examination and ufPWV imaging examination of all patients were collected.The modeling group obtained the theoretical elastic index equation using multiple stepby-step linear regression analysis.Then PWVI was calculated using this equation to further analyze the influence of atherosclerosis risk factors on PWVI.Result The theoretical elastic equation obtained from the modeling group was terminal contraction pulse wave velocity(PWV-ES)(m/s)=0.083×age(years)+0.036×mean arterial pressure(mmHg)+0.681×sex(female=0,male=1)+0.164,accordingly,the experimental groups were divided into elastic decline group(n=115,PWVI≥0)and normal elastic group(n=93,PWVI<0).Gender,total cholesterol(TC),high density lipoprotein(HDL),low density lipoprotein(LDL),fasting blood glucose and smoking history of the two groups were compared with each other,and there were statistically significant differences(P<0.05).The increase of PWVI were positively correlated with TC(r=0.251,P=0.006),LDL(r=0.401,P<0.01)levels,and HDL(r=-0.247,P<0.01)level was negatively correlated.Conclusion The detection of arterial elasticity index PWV-ES and its calculated PWVI based on ufPWV technique can be used as a non-invasive and reliable method to evaluate the progression of atherosclerotic elastic decline in hypertensive patients.

关 键 词：超极速脉搏波 脉搏波速度指数 高血压 动脉弹性衰退 

分 类 号：R543[医药卫生—心血管疾病]