含三唑基团的肉桂酸酯衍生物的合成及生物活性  

Synthesis and biological activity of cinnamate derivatives containing triazole group

作　　者：游江 王济海 刘贺 周强 YOU Jiang;WANG Jihai;LIU He;ZHOU Qiang(Synwill Yichang Chemical Co.,Ltd.,Hubei Yichang443000,China;Jingzhou Beimen Middle School,Hubei Jingzhou434000,China)

机构地区：[1]顺毅宜昌化工有限公司,湖北宜昌443000 [2]湖北省荆州市北门中学,湖北荆州434000

出　　处：《现代农药》2024年第4期29-37,共9页MODERN AGROCHEMICALS

摘　　要：将肉桂酸与含三唑基团的活性亚结构拼接设计合成了19个含三唑基团的肉桂酸酯衍生物Ⅵa~Ⅵs。化合物结构经过1H NMR、13C NMR和HRMS确证。生物活性测试结果显示:化合物Ⅵc对水稻恶苗病菌的EC50为9.22 mg/L,略高于对照药剂烯唑醇(6.14 mg/L)。在质量浓度为50 mg/L时,化合物Ⅵc对生姜青枯病菌的抑制率为22.24%,稍低于对照药剂20%噻菌铜悬浮剂(27.41%)。化合物Ⅵc具有一定的抑制真菌和细菌的活性,可作为先导化合物进一步研究。Nineteen cinnamate derivatives were designed and synthesized by splicing with the biologically active factor containing triazole group.The structures of the new compounds were characterized by 1H NMR,13C NMR and HRMS.The results of bioactivity tests showed that the EC50 of compoundⅥc against Fusarium moniliforme was 9.22 mg/L,which was higher than the EC50 of diniconazole(6.14 mg/L).At the concentration of 50 mg/L,the inhibition rate of compoundⅥc against Ralstonia solanacearum was 22.24%,which was lower than that of thiodiazole copper 20%SC(27.41%).CompoundⅥc had the activity of both antifungal and antibacterial,which could be used as a lead compound for the further study.

关 键 词：肉桂酸 三唑 新化合物 合成 生物活性 

分 类 号：TQ450.1[化学工程—农药化工]