联苯吡菌胺中间体2-(3,4-二氯苯基)-4-氟苯胺的合成研究  

Study on synthesis of bixafen intermediate 2-(3,4-dichlorophenyl)-4-fluoroaniline

作　　者：曹燕蕾[1] CAO Yanlei(Jiangsu Pesticide Institute Co.,Ltd.,Nanjing210046,China)

机构地区：[1]江苏省农药研究所股份有限公司,南京210046

出　　处：《现代农药》2024年第4期38-40,54,共4页MODERN AGROCHEMICALS

摘　　要：研究了联苯吡菌胺中间体2-(3,4-二氯苯基)-4-氟苯胺的合成路线。以3,4-二氯苯胺为起始原料,经重氮化、亚硫酸钠还原得到3,4-二氯苯肼,再与4-氟苯胺在碱性条件下通入空气偶联得到目标产物2-(3,4-二氯苯基)-4-氟苯胺。以3,4-二氯苯胺计,目标产物收率80%以上,质量分数90%以上。与其他工艺路线相比,该路线具有原料价廉、易于保存,操作简单,收率较高,易纯化等优点。In this paper,the synthetic routes of bixafen intermediate 2-(3,4-dichlorophenyl)-4-fluoroaniline were studied.3,4-Dichlorophenylhydrazine was prepared from 3,4-dichloroaniline by diazotization and reduction reaction,and then it was coupled with 4-fluoroaniline in air under alkaline conditions to obtain the target product.The yield of the target product was above 80%,and the content was more than 90%,calculated by 3,4-dichloroaniline.Compared with other process routes,this route had the advantages of cheap raw materials,easy preservation,simple operation,high yield,and easy purification.

关 键 词：2-(3 4-二氯苯基)-4-氟苯胺 联苯吡菌胺 3 4-二氯苯胺 4-氟苯胺 重氮化 合成 

分 类 号：O625.2[理学—有机化学]