氯氟醚菌唑的合成工艺研究  

Study on the synthesis process of mefentrifluconazole

作　　者：沈运河 祝玉超 夏东国 SHEN Yunhe;ZHU Yuchao;XIA Dongguo(Anhui Jiuyi Agrochemical Co.,Ltd.,Hefei230088,China)

机构地区：[1]安徽久易农业股份有限公司,合肥230088

出　　处：《现代农药》2024年第4期41-43,69,共4页MODERN AGROCHEMICALS

摘　　要：综述了氯氟醚菌唑的合成工艺路线,并提出合成氯氟醚菌唑的新工艺路线。以2-溴-5-氟-三氟甲苯为起始原料,经格氏、开环和醚化3步反应,得到氯氟醚菌唑。该合成路线具有反应条件温和,收率高,成本低,路线短等特点,适合工业化生产。The synthesis routes of mefentrifluconazole were summarized,and a new synthesis process was proposed in this paper.Mefentrifluconazole was prepared using 2-bromo-5-fluoro-benzotrifluoride as the starting material via reactions of Grignard reaction,ring-opening reaction,and etherification reaction.The synthetic route was suitable for industrial production with the advantages of mild reaction condition,high yield,low cost and simple procedures.

关 键 词：氯氟醚菌唑 2-溴-5-氟-三氟甲苯 工艺路线 合成 

分 类 号：TQ455.4[化学工程—农药化工]