血清前白蛋白联合白细胞介素-6水平检测对儿童喘息性支气管炎的预测价值  

Predictive Value of Serum Prealbumin Combined with Interleukin-6 in Children with Asthmatic Bronchitis

作　　者：朱华东 廖培成 Zhu Huadong(Department of Pediatrics,People's Hospital of Ganzhou City,Ganzhou Jiangxi 341000)

机构地区：[1]赣州市人民医院儿科,江西赣州341000

出　　处：《黑龙江医药》2024年第4期755-757,共3页Heilongjiang Medicine journal

基　　金：江西省卫生健康委科技计划(编号:SKJP220610679)。

摘　　要：目的:探讨血清前白蛋白与白细胞介素-6(IL-6)水平二者联合检测对儿童喘息性支气管炎的预测价值,为喘息性支气管炎患儿早期预防与诊治提供依据。方法:选取2021年8月2022年9月于赣州市人民医院100例支气管炎患儿为研究对象,根据患儿并发喘息情况分为喘息组与非喘息组各50例,运用酶联免疫吸附法检测两组患儿的血清前白蛋白、IL-6水平,分析收集的数据,绘制受试者工作曲线(ROC)曲线,分析血清前白蛋白与IL-6及二者联合检测对儿童喘息性支气管炎的预测价值。结果:喘息组患儿的血清前白蛋白表达水平低于非喘息组,差异有统计学意义(P<0.05),血清IL-6表达水平高于非喘息组,差异有统计学意义(P<0.05)。ROC曲线结果显示,血清前白蛋白、IL-6二者联合检测对患儿并发哮喘预测AUC为0.988,高于血清前白蛋白的0.858与IL-6的0.878,敏感度、特异度均高于单独检测。结论:喘息性支气管炎患儿血清前白蛋白水平降低,血清IL-6表达水平升高,二者联合检测早期诊断喘息性支气管炎的临床价值高,值得推广。Objective:Exploring the predictive value of the combined detection of serum prealbumin and interleukin-6(IL-6)levels for pediatric asthmatic bronchitis,providing a basis for early prevention and treatment of asthmatic bronchitis in children.Methods:Selecting 100 children with bronchitis at Ganzhou People's Hospital from August 2021 to September 2022 as the research subjects,they were divided into a wheezing group and a non wheezing group of 50 cases each based on their concurrent wheezing situation.Enzyme linked immunosorbent assay was used to detect the serum prealbumin and IL-6 levels of the two groups of children,analyze the collected data,draw receiver operating curve(ROC)curves,and analyze the predictive value of serum prealbumin and IL-6,as well as their combined detection,for pediatric wheezing bronchitis.Results:The expression level of serum prealbumin in the wheezing group was lower than that in the non wheezing group,and the difference was statistically significant(P<0.05).The expression level of serum IL-6 was higher than that in the non wheezing group,and the difference was statistically significant(P<0.05).The ROC curve results showed that the combined detection of serum prealbumin and IL-6 predicted an AUC of 0.988 for children with concurrent asthma,which was higher than 0.858 for serum prealbumin and 0.878 for IL-6,with higher sensitivity and specificity than single detection.Conclusion:The level of serum prealbumin in children with asthmatic bronchitis decreased,and the level of serum IL-6 expression increased.The two combined detection has high clinical value in early diagnosis of asthmatic bronchitis,and is worth popularizing.

关 键 词：儿童 喘息性支气管炎 非喘息性支气管炎 前白蛋白 白细胞介素-6 

分 类 号：R725.6[医药卫生—儿科]