糖萼损伤对炎症性肠病的诊断和监测价值  

Advances in the diagnostic and monitoring value of glycocalyx injury in inflammatory bowel disease

作　　者：张乐丹 靳明星 刘艳迪[2] ZHANG Ledan;JIN Mingxing;LIU Yandi(School of Medicine,Nankai University,Tianjin 300071,China;Department of Gastroenterology,Tianjin Union Medical Center)

机构地区：[1]南开大学医学院,300071 [2]天津市人民医院消化科

出　　处：《天津医药》2024年第8期893-896,共4页Tianjin Medical Journal

摘　　要：炎症性肠病(IBD)目前无法治愈,只能通过药物、手术等手段缓解症状,延缓和减少复发,因此对疾病活动度的监测至关重要。糖萼是覆盖于血管内皮细胞管腔侧的多糖蛋白复合物,对于维持肠道黏膜屏障具有支持作用,而炎症会导致其结构受损。该文介绍了目前临床上IBD在实验室检测中的无创性生物标志物,并分析了血清糖萼损伤标志物多配体蛋白聚糖1、硫酸乙酰肝素、透明质酸对IBD的诊断和监测价值。Inflammatory bowel disease(IBD)is no cure at present,and only drugs and surgery can relieve symptoms,delay and reduce recurrence.Therefore,it is very important to monitor the disease activity.Glycocalyx,a polyglycoprotein complex covering luminal side of vascular endothelial cells,is supportive in maintaining the intestinal mucosal barrier,and inflammation leads to its structural damage.This review introduces currently available non-invasive biomarkers of clinical importance for IBD in laboratory testing,and analyzes the value of serum glycocalyx injury markers(syndecan-1,HS and HA)in the diagnosis or monitoring of IBD.

关 键 词：炎性肠疾病 肠黏膜 多配体蛋白聚糖1 硫酸乙酰肝素 透明质酸 糖萼损伤 

分 类 号：R446.1[医药卫生—诊断学] R574.6[医药卫生—临床医学]