回阳通脉汤治疗寒湿阻络型下肢动脉粥样硬化闭塞症的临床研究  

Clinical Efficacy of Huiyang Tongmai Decoction in Treatment of Lower Extremity Atherosclerosis Obliterans Due to Cold-dampness Blocking Collaterals

作　　者：王雨[1] 徐旭英[1] WANG Yu;XU Xu-ying(Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)

机构地区：[1]首都医科大学附属北京中医医院,北京100010

出　　处：《中国现代中药》2024年第8期1414-1419,共6页Modern Chinese Medicine

基　　金：国家自然科学基金面上项目(81873118)。

摘　　要：目的:探讨回阳通脉汤治疗寒湿阻络型下肢动脉粥样硬化闭塞症(LEASO)的临床疗效。方法:将80例脾肾阳虚的LEASO患者按照随机数字表法分为两组,对照组给予贝前列素钠口服(40μg,3次/d),治疗组在对照组基础上联合回阳通脉汤加减治疗,以3个月为观察终点。比较两组患者中医证候评分,血液内皮素-1(ET-1)、一氧化氮(NO)水平,踝肱指数(ABI),经皮氧分压(TcPO_(2))及足背动脉血流动力学指标。结果:治疗组临床总有效率(90.00%)高于对照组(75.00%,P<0.05),两组患者治疗后中医证候各项评分均较治疗前降低(P<0.05),且治疗组优于对照组(P<0.05);两组患者治疗后ET-1水平均较治疗前降低(P<0.05),且治疗组优于对照组(P<0.05);两组患者治疗后NO水平、ABI、TcPO_(2)、足背动脉血流动力学指标均升高(P<0.05),且治疗组优于对照组(P<0.05)。结论:回阳通脉汤干预寒湿阻络型LEASO能够减轻患者缺血肢体症状,缓解间歇性跛行,提高ABI及TcPO_(2),改善足部血供。Objective:To explore the clinical efficacy of Huiyang Tongmai Decoction in the treatment of lower extremity atherosclerosis obliterans(LEASO)with syndrome of cold-dampness blocking collaterals.Methods:Eighty LEASO patients with spleen and kidney yang deficiency syndrome were divided into two groups according to the random number table method.The control group was given beraprost sodium orally(40μg,tid),and the treatment group was treated with Huiyang Tongmai Decoction in addition to the control group,with a 3-month observation period.Traditional Chinese medicine(TCM)syndrome scores,endothelin-1(ET-1),nitric oxide(NO),ankle-brachial index(ABI),transcutaneous oxygen partial pressure(TcPO_(2)),and dorsalis pedis artery hemodynamic indicators were compared between the two groups.Results:The total clinical effective rate of the treatment group(90.00%)was higher than that of the control group(75.00%,P<0.05).After treatment,the TCM syndrome scores in both groups were lower than those before treatment(P<0.05),with the treatment group showing greater improvement than the control group(P<0.05).ET-1 levels in both groups decreased after treatment(P<0.05),and the treatment group had lower levels than the control group(P<0.05).Levels of NO,ABI,TcPO_(2),and dorsalis pedis artery hemodynamic indicators increased in both groups after treatment(P<0.05),with the treatment group showing greater improvement than the control group(P<0.05).Conclusion:Huiyang Tongmai Decoction can reduce symptoms of ischemic limbs,relieve intermittent claudication,increase ABI and TcPO_(2),and improve blood supply to the foot in patients with LEASO.

关 键 词：回阳通脉汤 寒湿阻络证 下肢动脉粥样硬化闭塞症 随机对照研究 

分 类 号：R285.6[医药卫生—中药学]