中药防治痔病作用机制研究进展  

Research Progress in Mechanism of Traditional Chinese Medicine in Prevention and Treatment of Hemorrhoids

作　　者：黄泽森 韩梁 韩彦琪[2,3,4] 李新 卢朋 许浚 赵专友[2,3,4] 张铁军 HUANG Ze-sen;HAN Liang;HAN Yan-qi;LI Xin;LU Peng;XU Jun;ZHAO Zhuan-you;ZHANG Tie-jun(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine,Tianjin Institute of Pharmaceutical Research,Tianjin 300462,China;National&Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine,Tianjin Institute of Pharmaceutical Research,Tianjin 300462,China;Heguang Chinese Medicine Technology(Tianjin)Co.,Ltd.,Tianjin 300462,China)

机构地区：[1]天津中医药大学,天津301617 [2]天津药物研究院天津市中药质量标志物重点实验室,天津300462 [3]天津药物研究院中药现代制剂与质量控制技术国家地方联合工程实验室,天津300462 [4]和光中药科技(天津)有限公司,天津300462

出　　处：《中国现代中药》2024年第8期1432-1442,共11页Modern Chinese Medicine

摘　　要：痔病是以肛门黏膜静脉丛发生曲张为主要特征的慢性疾病,随着病程延长会伴有肿胀疼痛、黏液流出等病理表现,临床上表现为患处瘙痒、作痛、便血等。手术是治疗痔疮的有效方法之一,能够缓解病人痛苦,根治性较高。但手术费用昂贵,术后容易出现出血、肛门狭窄等不适。中药可通过多靶点、多途径发挥治疗痔病的作用,其作用机制主要是调控机体内外炎症反应、减轻脂质过氧化反应、抑制基质金属蛋白酶表达、调控血管生成和上调纤维蛋白的表达等。目前,对痔病的机制研究正逐渐深化,但尚未系统性阐述痔病发病及中药改善的作用机制,综述相关研究对防治痔病具有十分重要的意义。Hemorrhoids are a chronic disease mainly characterized by varicosity of the anal mucosal venous plexus.With the prolongation of the disease course,the patients with hemorrhoids will suffer from hematochezia,swelling pain,mucus discharge and other pathological changes.The clinical manifestations include pruritus,pain,and hematochezia.Surgery,one of the effective ways to treat hemorrhoids,can relieve the patient's pain and exert the curative effect.However,the operation is expensive,and the patients are prone to postoperative bleeding,anal stenosis,and other discomfort.Traditional Chinese medicine plays a role in the treatment of hemorrhoids via multiple targets and multiple ways,in which the mechanisms include regulating internal and external inflammation,reducing lipid peroxidation,inhibiting the expression of matrix metalloproteinases,modulating angiogenesis,and up-regulating the expression of fibulin.At present,the research on the mechanism of hemorrhoids is deepening,while the pathogenesis of this disease and the intervention mechanism of traditional Chinese medicine have not been systematically expounded.The review of relevant research is of great significance for the prevention and treatment of hemorrhoids.

关 键 词：痔 中药 发病机制 作用机制 

分 类 号：R282[医药卫生—中药学]