钯催化膦配体的Suzuki-Miyaura偶联  

Palladium-catalyzed Suzuki-Miyaura Coupling of Phosphine Ligands

作　　者：苏家春 陈英莲 左云婷 包美淇 谢兵[1] 苟铨 朱乾华[1] SU Jia-chun;CHEN Ying-lian;ZUO Yun-ting;BAO Mei-qi;XIE Bing;GOU Quan;ZHU Qian-hua(College of Chemistry and Chemical Engineering,Yangtze Normal University,Chongqing 408100,China)

机构地区：[1]长江师范学院化学化工学院,重庆408100

出　　处：《广州化工》2024年第12期23-25,共3页GuangZhou Chemical Industry

基　　金：国家级大学生创新创业训练计划项目“荧光颜料的研制及应用研究”(项目编号:202110647008)。

摘　　要：Suzuki-Miyaura反应是应用最广泛的交叉偶联反应之一,因此其研究具有重要的意义。目前,通过碳磷键的断裂实现Suzuki-Miyaura反应的研究鲜有报道。本研究旨在研究钯催化膦配体的Suzuki-Miyaura反应,通过膦试剂的筛选、催化剂的筛选、溶剂的筛选、溶剂浓度考察和反应温度考察,探究了各种反应参数对反应结果的影响。最优反应条件是:在Schlenk反应管中依次加入4,5-双(二苯基膦)-9,9-二甲基氧杂蒽(Xantphos)、二(乙酰丙酮)钯(Pd(acac)_(2))、对甲氧基苯硼酸(4-Methoxyphenylboronic acid)和3-戊酮(DEK),并于100℃下搅拌24 h。The Suzuki-Miyaura reaction was one of the most widely used cross-coupling reaction,so its research was of great significance.At present,little research has been reported on the Suzuki-Miyaura reaction achieved by the breakage of C-P bonds.This study aims to investigate the palladium-catalyzed Suzuki-Miyaura coupling of phosphine ligands.Through the screening of phosphorus reagents,catalysts,solvents,solvent concentration,and reaction temperature,the effects of various reaction parameters on the reaction results were explored.The optimal reaction conditions were as follows:The Xanthhos,Pd(acac)_(2),4-Methoxyphenylboronic acid and DEK are sequentially added to the Schlenk reaction tube,and then stirred at 100℃for 24 h.

关 键 词：Suzuki-Miyaura偶联反应 钯催化 磷化氢配体 

分 类 号：TQ423.2[化学工程]