On the Specificity of Nanozymes: A Perspective  

作　　者：Gen Wei Shuje Liu Yung-Kang Peng Hui Wei 

机构地区：[1]Department of Biomedical Engineering,College of Engineering and Applied Sciences,Nanjing National Laboratory of Microstructures,Jiangsu Key Laboratory of Artificial Functional Materials,Nanjing University,Nanjing,Jiangsu 21023,China [2]Department of Chemistry.City University of Hong Kong,Hong Kong 999077,Hong Kong SAR,China [3]State Key Laboratory of Analytical Chemistry for Life Science,School of Chemistry and Chemical Engineering,Chemistry and Biomedicine Innovation Center(ChemBIC),Nanjing University,Nanjing,Jiangsu 210023,China [4]NMPA Key Laboratory for Biomedical Optics,Hangzhou,Zhejiang 310018,China

出　　处：《Chinese Journal of Chemistry》2024年第13期1515-1522,共8页中国化学（英文版）

基　　金：This work was supported by National Key R&D Program of China(2021YFF1200700 and 2019YFA0709200);National Natural Science Foundation of China grant(22374071);Jiangsu Provincial Key R&D Program(BE2022836);CAS Interdisciplinary Innovation Team(JCTD-2020-08);PAPD Program,State Key Laboratory of Analytical Chemistry for Life Science(5431ZZXM2306);NMPA Key Laboratory for Biomedical Optics(20240001);Fundamental Research Funds for the Central Universities(021314380228)。

摘　　要：We have compiled eight promising strategies for enhancing the specificity and selectivity of nanozymes,as depicted in the comprehensive summary above.Enzymes exhibit intricate and sophisticated structures,including substrate channels and active sites,which can inform the design of nanozymes.Replication of these structural features and the application of facet engineering/doping techniques can significantly enhance the catalytic specificity of nanozymes.Alternatively,the use of Molecularly Imprinted Polymers(MiPs)to coat nanozymes represents an effective approach to impart substrate specificity.Furthermore,several straightforward stopgap strategies have been devised to improve nanozyme specificity for analytical applications,such as the integration of biorecognition elements and nanozyme sensor arrays through surface modification.

关 键 词：Nanozymes ENZYMES Catalytic activity SPECIFICITY PERSPECTIVE 

分 类 号：O64[理学—物理化学]