Stereoselectiveα-Glycosylation with GlcN_(3)Donors Enabled Collective Syntheses of Acinetobacter baumannii Capsular Polysaccharides K43,K47 and K88 Repeating Units  

作　　者：Kunxiu Shou Shanshan Liu Yunqin Zhang Guozhi Xiao 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Kunming,Yunnan,650201 China

出　　处：《Chinese Journal of Chemistry》2024年第14期1593-1598,共6页中国化学（英文版）

基　　金：supports from National Natural Science Foundation of China(22322110);the CAS Pioneer Hundred Talents Program(No.2017-128);Yunnan Province Science and Technology Department(202305AH340005);the Young Talents Project of High-level Talent Introduction Program of Yunnan Province are greatly acknowledged。

摘　　要：Collective syntheses of A.baumannii CPS K43,K47 and K88 repeating units have been accomplished via a newα-glycosylation method with GlcN_(3) as donors,which features:1)mild reaction conditions,2)good to high yields,3)excellent stereoselectivities.The synthetic route also highlights an orthogonal one-pot coupling strategy on the basis of glycosyl ortho-(1-phenylvinyl)benzoates for stereoselective constructions of both 1,2-trans and 1,2-cis glycosidic bonds,precluding the issues of aglycone transfer.

关 键 词：A baumanni CPS α-Glycosylation method One-pot glycosylation 1 2-GlcN bonds Glycosyl ortho-(1-phenylvinyl)benzoates Carbohydrates OLIGOSACCHARIDES Total synthesis 

分 类 号：O62[理学—有机化学]