Annulation Cascades of Cyclosulfonium Salts and Alkenes towards Sulfur-Containing N-Heterocycles by Visible Light/Copper Catalysis  

作　　者：Jie Ma Xufeng Li Yuqing Chen Yongjia Shi Xiuyan Song Jian Lv Daoshan Yang 

机构地区：[1]Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science,MOE,College of Chemistry and Molecular Engineering,Qingdao University of Science and Technology,Qingdao,Shandong,266042 China [2]Zhejiang Wansheng Co.,Ltd.,Linhai,Zhejiang,317000 China [3]National Engineering Research Center of Low-Carbon Processing and Utilization of Forest Biomass,Nanjing Forestry University,Nanjing,Jiangsu,210037 China

出　　处：《Chinese Journal of Chemistry》2024年第14期1637-1643,共7页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(22271170);the Scientific Research Foundation of Qingdao University of Science and Technology.

摘　　要：Although,great achievements have been made in the synthesis of heterocycles using radical addition/cyclization strategy,developing versatile alkyl radical precursors,especially the non-stabilized long chain alkyl radicals for this strategy still remains a huge challenge.Herein,we report an efficient annulation cascade reaction between cyclosulfonium salts and alkenes for the synthesis of sulfur-containing N-heterocycles by visible light/copper catalysis under mild conditions.The C—S bond cleavage/radical cascade reaction delivers a variety of corresponding N-heterocycles containing aryl alkyl thioether motifs with good functional group tolerance.Significantly,the current system could be used for the late-stage functionalization of complex bioactive molecules.

关 键 词：Visible light Radical reactions C-C coupling Sulfur heterocycles Photoredox catalysis 

分 类 号：O62[理学—有机化学]