Endocan与Galectin-3在微血管性心绞痛患者血清中的表达及其诊断价值  

Expression and Diagnostic Value of Endocan and Galectin-3 in Serum of Patients with Microvascular Angina

作　　者：陈敬 王永强 刘猛 CHEN Jing;WANG Yongqiang;LIU Meng(Department of Medical Laboratory,Yanji County People's Hospital,Xinxiang Henan 453200)

机构地区：[1]延津县人民医院医学检验科,河南新乡453200 [2]新乡市中心医院检验科,河南新乡453000 [3]郑州大学第二附属医院检验科,河南郑州450000

出　　处：《医学临床研究》2024年第7期1041-1043,1047,共4页Journal of Clinical Research

摘　　要：【目的】探讨内皮细胞特异分子-1(Endocan)与半乳糖凝集素-3(Galectin-3)在微血管性心绞痛(CMSA)患者血清中的表达及其诊断价值。【方法】延津县人民医院收治的87例CMSA患者作为观察组,另选取院内同期体检的87例健康者作为对照组,比较两组的临床资料和血清Endocan与Galectin-3表达水平。采用Logistic多因素回归分析CMSA的影响因素;以受试者工作特征(ROC)曲线下面积(AUC)评估血清Endocan与Galectin-3水平对CMSA的诊断价值。【结果】观察组糖尿病、高血压占比及空腹血糖、血清Endocan、Galectin-3水平均高于对照组(P<0.05)。Logistic多因素回归分析结果显示,糖尿病、高血压、空腹血糖及血清Endocan、Galectin-3表达水平升高均为CMSA的危险因素(P<0.05)。ROC曲线分析显示,血清Endocan、Galectin-3水平单一及联合检测诊断CMSA的AUC分别为0.731、0.785和0.891。【结论】CMSA患者血清Endocan与Galectin-3均存在高表达,且血清Endocan与Galectin-3在CMSA诊断中的效能较高。【Objective】To investigate the expression and diagnostic value of endothelial cell-specific molecule-1(Endocan)and Galectin-3 in the serum of patients with microvascular angina(CMSA).【Methods】A total of 87 CMSA patients treated at Yanji County People's Hospital were selected as the observation group,while 87 healthy individuals during the same period were selected as the control group.The relevant data and serum Endocan and Galectin-3 expression levels of the two groups were compared.Logistic multivariate regression analysis was used to analyze the influencing factors of CMSA.The diagnostic value of serum Endocan and Galectin-3 levels for CMSA was evaluated by the area under the receiver operating characteristic(ROC)curve(AUC).【Results】The proportions of diabetes,hypertension,and high levels of fasting blood glucose,serum Endocan and Galectin-3 in the observation group were higher than those in the control group(P<0.05).Logistic multivariate regression analysis showed that increased levels of diabetes,hypertension,fasting blood glucose,serum Endocan,and Galectin-3 were risk factors for CMSA(P<0.05).ROC analysis showed that the AUC of serum Endocan,Galectin-3,and their combined detection for diagnosing CMSA were 0.731,0.785,and 0.891,respectively.【Conclusion】There is a high expression of serum Endocan and Galectin-3 in CMSA patients,and the diagnostic valueefficacy of serum Endocan and Galectin-3 in CMSA is high.

关 键 词：微血管性心绞痛 半乳糖凝集素3/血液 

分 类 号：R541.4[医药卫生—心血管疾病]