热毒宁注射液联合阿奇霉素治疗小儿支原体肺炎的临床效果及对炎性因子水平的影响  

Effect of Reduning injection combined with azithromycin in the treatment of Mycoplasma pneumonia in children and its influence on the levels of inflammatory factors

作　　者：赵丽菲 ZHAO Li-fei(Department of Pediatrics,Huangzhou District People's Hospital,Huanggang 438000,China)

机构地区：[1]湖北省黄冈市中环路黄州区人民医院儿科,438000

出　　处：《中国实用医药》2024年第14期110-113,共4页China Practical Medicine

摘　　要：目的探究热毒宁注射液联合阿奇霉素治疗小儿支原体肺炎的临床效果。方法以48例小儿支原体肺炎患儿作为研究对象,随机分成对照组和观察组,各24例。对照组给予常规阿奇霉素治疗,观察组在此基础上联合热毒宁注射液治疗。对比两组患儿临床疗效、各项症状改善时间以及治疗前后的T淋巴细胞亚群水平、血清炎性因子水平。结果观察组治疗总有效率为100.00%,显著高于对照组的79.17%(P<0.05)。观察组发热消退时间(2.42±0.55)d、咳嗽消失时间(6.41±1.31)d以及肺部啰音消失时间(4.54±1.07)d均显著短于对照组的(3.67±1.01)、(8.57±2.58)、(6.61±1.43)d(P<0.05)。治疗后,观察组CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)分别为(51.78±6.10)%、(47.14±5.52)%、(22.90±4.53)%、(2.46±0.84);对照组CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)分别为(46.16±7.27)%、(42.93±7.81)%、(25.23±1.69)%、(1.41±0.58)。治疗后观察组CD8^(+)低于对照组,CD3^(+)、CD4^(+)以及CD4^(+)/CD8^(+)均高于对照组(P<0.05)。治疗后,两组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平均改善,且观察组TNT-α、IL-6、CRP分别为(46.09±3.47)ng/L、(6.05±1.27)pg/ml、(4.05±1.09)mg/L,均显著优于对照组的(59.77±4.55)ng/L、(7.47±1.94)pg/ml、(5.39±1.25)mg/L(P<0.05)。结论小儿支原体肺炎使用阿奇霉素联合热毒宁注射液治疗有效率较高,能促进患儿康复,可在临床中加以大力推广。Objective To explore the clinical effect of Reduning injection combined with azithromycin in the treatment of Mycoplasma pneumonia in children.Methods 48 children with Mycoplasma pneumonia were selected as the research subjects,and they were randomly divided into a control group and an observation group,with 24 cases in each group.The control group was treated with conventional azithromycin,while the observation group was combined with Reduning injection on this basis.The clinical efficacy,symptom improvement time,T-lymphocyte subsets and serum inflammatory factors before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 100.00%,which was significantly higher than 79.17%of the control group(P<0.05).In the observation group,the fever resolution time was(2.42±0.55)d,the cough disappearance time was(6.41±1.31)d and the lung rale disappearance time was(4.54±1.07)d,which were significantly shorter than(3.67±1.01),(8.57±2.58)and(6.61±1.43)d in the control group(P<0.05).After treatment,CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)in the observation group were(51.78±6.10)%,(47.14±5.52)%,(22.90±4.53)%,(2.46±0.84);in the control group,CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)were(46.16±7.27)%,(42.93±7.81)%,(25.23±1.69)%,(1.41±0.58).After treatment,the observation group had lower CD8^(+)than that in the control group;CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group(P<0.05).After treatment,the tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)in both groups were improved;TNF-α,IL-6 and CRP in the observation group were(46.09±3.47)ng/L,(6.05±1.27)pg/ml and(4.05±1.09)mg/L,which were significantly better than(59.77±4.55)ng/L,(7.47±1.94)pg/ml and(5.39±1.25)mg/L in the control group(P<0.05).Conclusion The use of azithromycin combined with Reduning injection in the treatment of Mycoplasma pneumonia in children has a higher effective rate and can promote the recovery of

关 键 词：小儿支原体肺炎 阿奇霉素 热毒宁 肺功能 应激指标 

分 类 号：R725.6[医药卫生—儿科]