新型袢利尿剂托拉塞米在心衰患者临床治疗中的应用研究进展  

Research progress on the application of new loop diuretic torsemide in the clinical treatment of patients with heart failure

作　　者：冯春前 赖晖明 FENG Chun-qian;LAI Hui-ming(Department of Internal Medicine,the Fifth People's Hospital of Longgang District,Shenzhen 518000,China)

机构地区：[1]深圳市龙岗区第五人民医院内科,518000

出　　处：《中国实用医药》2024年第14期178-180,共3页China Practical Medicine

摘　　要：心力衰竭(心衰)是指心脏功能不足,无法满足身体需要的一种疾病。袢利尿剂是一种利尿剂,可用于心衰患者的临床治疗。该药物可作用于肾小管上升段的升支粗段和细段,抑制钠、氯、镁和钙的重吸收,增加尿量和钠的排泄,以减轻心脏负荷。托拉塞米是一种新型袢利尿剂,在心衰患者临床治疗中的应用效果备受关注,该药物是一种高效的袢利尿剂,与传统袢利尿剂相比,具有多方面优势但该药物的作用机制也更为复杂。如托拉塞米可作用于肾小管升支粗段的Na^(+)-K^(+)-2Cl^(-)共转运体(NKCC2)上,抑制Na^(+)-K^(+)-2Cl^(-)的重吸收,增加尿量和钠的排泄,以减轻心脏负荷。为此,本文就新型袢利尿剂托拉塞米在心衰患者临床治疗中的应用研究进展进行了综述。Heart failure refers to a disease in which the heart does not function well enough to meet the body's needs.Loop diuretics are a type of diuretic that can be used in the clinical treatment of patients with heart failure.The drug can act on the thick and thin segments of the ascending branch of the ascending segment of the renal tubule,inhibit the reabsorption of sodium,chloride,magnesium and calcium,and increase the volume of urine and the excretion of sodium to reduce the cardiac load.Torsemide is a new loop diuretic,and its application effect in the clinical treatment of patients with heart failure has attracted much attention.Torsemide is a highly efficient loop diuretic,which has many advantages compared with traditional loop diuretics,but its mechanism of action is also more complex.For example,torsemide can act on the Na^(+)-K^(+)-2Cl^(-)cotransporter(NKCC2)in the thick segment of the ascending branch of the renal tubule,inhibit the reabsorption of Na^(+)-K^(+)-2Cl^(-),increase urine output and sodium excretion to reduce the cardiac load.In this regard,this article reviews the progress of research on the application of torsemide,a new loop diuretic,in the clinical management of patients with heart failure.

关 键 词：新型袢利尿剂 托拉塞米 心力衰竭 临床治疗 应用 研究进展 

分 类 号：R541.6[医药卫生—心血管疾病]