昼夜节律紊乱与胚胎着床失败关系的研究进展  

Advances in the study of the relationship of circadian rhythm disorder and embryo implantation failure

作　　者：庹银凤 王宝 王清仪 陈璐[2] 冯晓玲[2] Tuo Yin-feng;Wang Bao;Wang Qing-yi;Chen Lu;Feng Xiao-ling(Heilongjiang University of Traditional Chinese Medicine,Harbin,Heilongjiang 150006,China;The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin,Heilongjiang 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150006 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《中国现代医学杂志》2024年第15期58-64,共7页China Journal of Modern Medicine

基　　金：国家自然科学基金面上项目(No:8217150728);黑龙江省重点研发计划项目(No:2022ZX06C19);校基金-博士创新基金(No:2018BS07);黑龙江省高等学校青年创新人才培养计划(No:UNPYSCT-2020234)。

摘　　要：胚胎着床失败可能与昼夜节律紊乱有关。人体的生理功能和代谢活动受昼夜节律的调控,昼夜节律紊乱可能对生殖系统功能产生负面影响。昼夜节律紊乱会导致激素分泌异常、免疫功能紊乱及细胞周期调控失衡,这些因素可能影响子宫内膜的状态和胚胎着床过程。因此,维持良好的昼夜节律对于胚胎着床的成功至关重要。该综述旨在探讨昼夜节律与胚胎着床失败的关系,以此为基础进行调护,为隐性流产患者提供更有效的治疗策略,从而提高胚胎植入成功的机会。Embryo implantation failure may be associated with circadian disturbances.Studies have shown that the human physiological function and metabolic activities are regulated by the circadian rhythm,and this rhythm disturbance may negatively affect the reproductive system function.Circadian rhythm disorder can lead to abnormal hormone secretion,disturbed immune function and imbalance of cell cycle regulation,all of which may affect the state of the endometrium and the process of embryo implantation.Therefore,maintaining a good circadian rhythm is crucial for successful embryo implantation.Here,we aimed to explore the correlation between circadian rhythm and embryo implantation failure,based on which conditioning was performed to provide more effective treatment strategies for patients with recessive abortion,thus improving the chance of successful embryo implantation.

关 键 词：胚胎着床失败 昼夜节律紊乱 配子发生 胚胎 

分 类 号：R714.8[医药卫生—妇产科学]