Ocular syphilis:a case series of four patients and a review of the literature  

作　　者：Madeline Beckman Lana M.Rifkin 

机构地区：[1]Department of Ophthalmology and Visual Sciences,The Ohio State University,Columbus,OH,USA [2]Ophthalmic Consultants of Boston,Uveitis Service,Boston,MA,USA

出　　处：《Annals of Eye Science》2024年第2期62-70,共9页眼科学年鉴（英文）

摘　　要：Background:The incidence of syphilis has been increasing in the United States over the last two decades,with a more recent increase among women.Ocular syphilis is an uncommon but important complication of syphilis,most often presenting as posterior or panuveitis in late or latent syphilis of unknown duration.Untreated ocular syphilis may lead to permanent vision loss,underscoring the importance of appropriate evaluation and treatment of ocular syphilis.Case Description:In a retrospective,non-contiguous case series,we highlight four patients diagnosed and treated with ocular syphilis at a single institution.Four presentations of ocular syphilis are illustrated:anterior and intermediate uveitis,optic neuritis,posterior uveitis,and panuveitis.All patients initially presented with a decreased visual acuity(VA).One patient had a previous diagnosis of human immunodeficiency virus(HIV).Three patients were treated with intravenous(IV)penicillin and one patient with IV ceftriaxone.All had a return to their baseline VA after their course of treatment.Conclusions:Syphilis may go undetected without a high index of clinical suspicion due to its nonspecific presentations.All patients with ocular inflammation should have syphilis testing as a part of their infectious workup with both treponemal and non-treponemal testing.Patients diagnosed with syphilis and are not known to be HIV-negative should undergo testing for HIV due to the high rate of co-infection.Early diagnosis and prompt treatment after onset of symptoms may contribute to a more favorable prognosis for ocular syphilis.

关 键 词：Ocular syphilis UVEITIS CHOROIDITIS intermediate uveitis case series 

分 类 号：R759.1[医药卫生—皮肤病学与性病学] R77[医药卫生—临床医学]