阴道微生态特征与人乳头瘤病毒感染的相关性分析  

Correlation analysis between vaginal microbiota characteristics and human papillomavirus infection

作　　者：陈敏 陈涛 Chen Min;Chen Tao(Department of Obstetrics and Gynecology,Suining County Maternal and Child Health Hospital,Suining 221200,China)

机构地区：[1]睢宁县妇幼保健院妇产科,江苏睢宁221200

出　　处：《实用妇科内分泌电子杂志》2024年第18期14-16,35,共4页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的分析阴道微生态特征与人乳头瘤病毒(HPV)感染的相关性。方法选取1686例行阴道微生态与HPV检查的患者,分析患者混合性阴道炎构成情况、阴道微生态特征与HPV相关性、单纯性阴道炎与HPV相关性。结果1686例患者中,阴道微生态菌正常者1063例(占63.05%),菌群抑制47例(占2.79%),单纯性阴道炎检出405例(占24.02%),混合性阴道炎检出171例(占10.14%)。HPV阴性患者的阴道微生态的pH值、菌群密集度、乳杆菌分级、白细胞酯酶计数与HPV阳性患者比较,差异有统计学意义(P<0.05)。单纯性阴道炎外阴阴道假丝酵母菌病(VVC)和需氧性阴道炎(AV)与HPV感染存在相关性,其中VVC与HPV感染成正相关,AV与HPV感染成负相关(P<0.05)。结论阴道微生态异常与HPV感染相关,阴道微生态的特征为HPV感染情况和管理提供了有效的依据。Objective To analyze the correlation between vaginal microecological characteristics and human papillomavirus(HPV)infection.Methods 1686 patients who underwent vaginal microecology and HPV examination were selected to analyze the composition of mixed vaginitis,the correlation between vaginal microecology and HPV,and the correlation between simple vaginitis and HPV.Results Among the 1686 patients,1063 cases(63.05%)of vaginal microflora were normal,47 cases(2.79%)of bacterial inhibition,405 cases(24.02%)of simple vaginitis and 171 cases(10.14%)of mixed vaginitis were detected.There were significant differences in pH value,bacterial population density,lactobacillus grade and leukocyte esterase count between HPV-negative patients and HPV-positive patients(P<0.05).Simple vaginitis vulvovaginal candidiasis(VVC)and aerobic vaginitis(AV)were correlated with HPV infection,VVC was positively correlated with HPV infection,and AV was negatively correlated with HPV infection(P<0.05).Conclusion Abnormal vaginal microecology is associated with HPV infection,and the characteristics of vaginal microecology provide an effective basis for the condition and management of HPV infection.

关 键 词：阴道微生态 人乳头瘤病毒感染 相关性 

分 类 号：R711.32[医药卫生—妇产科学]