不同雌激素治疗薄型子宫内膜不孕症患者的临床观察  

Clinical observation of different estrogens in the treatment of thin endometrium infertility patients

作　　者：李亚梅[1] 张春花[1] 陈丽娜 金玉霞 李静[1] Li Yamei;Zhang Chunhua;Chen Lina;Jin Yuxia;Li Jing(Recurrent Abortion Clinic,Women and Children's Health Research Center,Gansu Provincial Maternal and Child Health Hospital,Lanzhou 730050,China)

机构地区：[1]甘肃省妇幼保健院妇幼保健科研中心复发性流产门诊,甘肃兰州730050

出　　处：《实用妇科内分泌电子杂志》2024年第18期39-43,共5页Electronic Journal of Practical Gynecological Endocrinology

基　　金：新疆维吾尔自治区重大科技专项(编号2022A02013-3)。

摘　　要：目的探究不同雌激素药物对薄型子宫内膜不孕症的临床治疗效果。方法选取本院门诊部收治的100例薄型子宫内膜不孕症患者为研究对象,随机分为两组,各50例。试验组口服结合雌激素片,对照组口服戊酸雌二醇片,比较两组患者治疗前后子宫内膜厚度变化、不良反应发生情况、妊娠率情况。结果治疗后,试验组和对照组子宫内膜厚度均增加,且试验组子宫内膜厚度增加大于对照组(P<0.05)。试验组妊娠率高于对照组,不良反应发生率低于对照组,但组间比较差异无统计学意义(P>0.05)。结论薄型子宫内膜不孕症雌激素药物治疗中,结合雌激素片效果更好,用药后子宫内膜厚度变化及妊娠率均优。Objective To explore the clinical therapeutic effects of different estrogen drugs on thin endometrium infertility.Methods 1oo patients with thin endometrial infertility admitted to the outpatient department of our hospital were selected as the research subjects,and randomly divided into two groups,with 50 cases in each group.The experimental group took orally conjugated estrogens tablets,while the control group took orally estradiol valerate tablets.The changes in endometrial thickness,adverse reactions,and pregnancy rates before and after treatment were compared between the two groups of patients.Results After treatment,the endometrial thickness of both the experimental group and the control group increased,and the increase in endometrial thickness in the experimental group was greater than that in the control group(P<0.05).The pregnancy rate in the experimental group was higher than that in the control group,and the adverse reactions were lower in the incidence rate than in the control group,but there was no statistically significant difference between the groups(P>0.05).Conclusion In the treatment of thin endometrium infertility with estrogen medication,the conjugated estrogens tablets are more effective.The changes in endometrial thickness and pregnancy rate and after medication are better than those in the control group.

关 键 词：薄型子宫内膜不孕症 结合雌激素 戊酸雌二醇 临床疗效 

分 类 号：R711.6[医药卫生—妇产科学]