D152树脂预洗工艺对大观霉素质量的影响  

Influence of D152 Resin Prewashing Process on the Quality of Spectinomycin

作　　者：王成 李海超 WANG Cheng;LI Haichao(Hebei Shengxue Dacheng Pharmaceutical Co.,Ltd.,Shijiazhuang 051430,China)

机构地区：[1]河北圣雪大成制药有限责任公司,河北石家庄051430

出　　处：《铀矿冶》2024年第3期68-73,共6页Uranium Mining and Metallurgy

摘　　要：大观霉素(Spectinomycin)是一种碱性水溶性氨基糖苷类抗生素,由壮观链霉(Actinospectacin)发酵产生。在用D152树脂提纯大观霉素过程中,引入EDTA-2Na预洗工艺,通过选择合适的预洗液浓度、pH和流速,实现高纯度盐酸大观霉素的提取,并确定了EDTA-2Na的回收工艺。研究得到了最佳预洗工艺参数:EDTA-2Na洗液浓度为0.015 mol/L,预洗液pH为7.5~8.0,流速为1.0~2.0 BV/h。该工艺简便易行、成本低、回收率高,保证了D152树脂的吸附收率,实现了绿色提取。Spectinomycin is an alkaline water-soluble aminoglycoside antibiotic,produced by the fermentation of actinospectacin.The prewashing process of D152 resin with EDTA-2Na was studied,by selecting the proper concentration,pH and flow rate of the prewashing solution,the extraction of high purity macromycin hydrochloride was realized,and the recovery process of EDTA-2Na was determined.The optimal prewashing parameters were obtained:the concentration of EDTA-2Na solution is 0.015 mol/L,the pH of prewashing solution is 7.5~8.0,and the flow rate is 1.0~2.0 BV/h.The prewashing process is simple,low cost and high recovery,which ensures the adsorption yield of D152 resin and realizes the green extraction.

关 键 词：大观霉素 D152树脂 预洗工艺 EDTA-2Na 

分 类 号：TQ465[化学工程—制药化工] O647.31[理学—物理化学]