多糖基温敏可注射型水凝胶的研究与应用进展  

Research and application progress on polysaccharides-based thermosensitive injectable hydrogels

作　　者：孙萌 孙惠[1,3] 姜硕 田野 刘鹰 李苗 SUN Meng;SUN Hui;JIANG Shuo;TIAN Ye;LIU Ying;LI Miao(College of Marine Science and Environment,Dalian Ocean University,Dalian 116023,Liaoning,China;College of Biosystems Engineering and Food Science,Zhejiang University,Hangzhou 310058,Zhejiang,China;Key Laboratory of Environment Controlled Aquaculture,Dalian Ocean University,Dalian 116023,Liaoning,China;School of Biological Engineering,Dalian Polytechnic University,Dalian 116034,Liaoning,China)

机构地区：[1]大连海洋大学海洋科技与环境学院,辽宁大连116023 [2]浙江大学生物系统工程与食品科学学院,浙江杭州310058 [3]大连海洋大学设施渔业教育部重点实验室,辽宁大连116023 [4]大连工业大学生物工程学院,辽宁大连116034

出　　处：《精细化工》2024年第8期1679-1692,共14页Fine Chemicals

基　　金：国家自然科学基金项目(22108024,31901775);辽宁省自然基金资助计划(面上)项目(2023-MS-285);辽宁省教育厅高校基本科研项目(20220062);大连市青年科技之星项目(2021RQ113,2022RQ016);设施渔业教育部重点实验室(大连海洋大学)资助项目(202224)。

摘　　要：多糖基温敏可注射型水凝胶作为一类智能软物质材料,在不同温度的刺激下能够实现液态溶胶-固态凝胶的可逆转变,具有生物相容性高、生物降解性强及物理和化学特性可调控等优势,在生物医学领域受到了广泛关注。该文概括了温敏可注射型水凝胶的溶胶-凝胶相转变机理;阐述了设计与合成多糖基温敏可注射型水凝胶的策略,包括小分子基团修饰多糖、合成型温敏聚合物接枝多糖、添加剂改性多糖;综述了多糖基温敏可注射型水凝胶在伤口愈合、药物递送和软骨修复生物医学领域中的应用,并对该领域存在的优化原料组成及设计策略、开发多样化环境刺激响应、增强机械强度和稳定性三方面的挑战提出建议;最后,对拓展多糖基水凝胶产品应用范围、加速推进其大范围临床应用进行了展望。Polysaccharides-based thermosensitive injectable hydrogels,a class of smart soft-matter materials which are capable of achieving reversible liquid-solid transition under temperature stimuli and show the advantages of high biocompatibility,biodegradability,and tunable physical and chemical properties,have attracted wide attention in the biomedical field.Herein,the sol-gel phase transition mechanism of thermosensitive injectable hydrogels was summarized.The strategies for design and synthesis of polysaccharides-based thermosensitive injectable hydrogels,including small molecule group modified polysaccharides,synthetic thermosensitive polymer grafted polysaccharides,additive modified polysaccharides,were described.The applications of polysaccharides-based thermosensitive injectable hydrogels in the biomedical field such as wound healing,drug delivery and cartilage repair were reviewed.The challenges of optimizing raw material composition and design strategy,developing diversified environmental stimulus responses,and enhancing mechanical strength and stability were also discussed.Finally,the prospect of expanding the application scope of polysaccharide-based hydrogel and accelerating their wide-scale clinical application was proposed.

关 键 词：可注射型 水凝胶 多糖 温度敏感性 伤口愈合 药物递送 软骨修复 

分 类 号：TQ427.26[化学工程]