指长比(2D∶4D)与胶原蛋白基因家族单核苷酸多态性的关联性  

Association between the digit ratio(2D︰4D)and single nucleotide polymorphisms of collagen gene family

作　　者：杨梦怡 张静[1] 牛世博 马成凤 徐彧 党洁[1] 马占兵[1] 霍正浩[1] 陆宏[1] Yang Mengyi;Zhang Jing;Niu Shibo;Ma Chengfeng;Xu Yu;Dang Jie;Ma Zhanbing;Huo Zhenghao;Lu Hong(Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education,Basic Medical College,Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学教育部生育力保持省部共建重点实验室,基础医学院,银川750004

出　　处：《解剖学杂志》2024年第3期205-210,共6页Chinese Journal of Anatomy

基　　金：国家自然科学基金(32160211,31960195)。

摘　　要：目的:探讨指长比(2D︰4D)与胶原蛋白基因家族4个基因COL4A2、COL5A1、COL6A2、COL10A1的10个单核苷酸多态性位点(rs3809346、rs3825490、rs7984100、rs1134170、rs3128575、rs1042917、rs2839110、rs3812111、rs1064583、rs2228547)的关联性。方法:采用体质测量法和多重PCR法,分别对2D︰4D及COL4A2、COL5A1、COL6A2和COL10A1基因多态性在宁夏地区大学生的分布特征进行比较,并分析其间的关联性。结果:宁夏女性大学生双手2D︰4D均值均显著高于男性;10个位点基因型和等位基因分布频率性别间均无显著差异;COL4A2基因rs3825490和rs3809346位点基因型分别与男性和女性双手2D︰4D显著关联,COL5A1基因rs1134170位点基因型和COL6A2基因rs1042917位点基因型分别与女性左手2D︰4D和男性右手2D︰4D显著关联。结论:宁夏人群2D︰4D的形成可能与COL4A2(rs3809346、rs3825490)、COL5A1(rs1134170)及COL6A2(rs1042917)基因多态性有关。Objective:To investigate the association of the digit ratio(2D︰4D)with ten single nucleotide polymorphism sites(rs3809346,rs3825490,rs7984100,rs1134170,rs3128575,rs1042917,rs2839110,rs3812111,rs1064583,rs2228547)in four genes(COL4A2,COL5A1,COL6A2,COL10A1)of collagen gene family.Methods:The distribution characteristics of 2D︰4D and COL4A2,COL5A1,COL6A2,and COL10A1genes polymorphisms among college students in Ningxia Hui Autonomous Region were compared by using physical measurement and multiplex PCR,respectively,and the association between them was analyzed.Results:The mean 2D︰4D of both hands were significantly higher in Ningxia female college students than that in males.There were no significant sex differences in the genotype and allele distribution frequencies of the ten loci.The COL4A2 rs3825490and rs3809346 loci genotypes were significantly associated with 2D︰4D of both hands in males and females,respectively,and the genotypes of COL5A1 rs1134170 and COL6A2 rs1042917 loci were significantly associated with 2D︰4D in left hand of females and 2D︰4D in right hand of males,respectively.Conclusion:The formation of 2D︰4D in Ningxia population may be related to the polymorphisms of COL4A2(rs3809346,rs3825490),COL5A1(rs1134170),and COL6A2(rs1042917)genes.

关 键 词：指长比 胶原蛋白基因 单核苷酸多态性 宁夏 

分 类 号：Q983[生物学—人类学]