中医药调控肿瘤相关巨噬细胞防治肺癌转移的基础研究进展  

Advances of Fundamental Research on Traditional Chinese Medicine in Regulation of Tumor-associated Macrophages for the Prevention and Treatment of Lung Cancer Metastasis

作　　者：刘诗卉 李佳轩 阙祖俊 于盼 田建辉[1,2] Shihui LIU;Jiaxuan LI;Zujun QUE;Pan YU;Jianhui TIAN(Clinical Oncology Center,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China;Institute of Oncology,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院肿瘤临床医学中心,上海200071 [2]上海中医药大学附属市中医医院肿瘤研究所,上海200071

出　　处：《中国肺癌杂志》2024年第7期541-549,共9页Chinese Journal of Lung Cancer

基　　金：国家自然科学基金面上项目(No.82174245);上海市炎癌转化病证生物学前沿研究基地项目(No.2021KJ03-12);上海市卫生健康领军人才项目(No.2022LJ014)资助。

摘　　要：肺癌是全球死亡率最高的癌种,而转移则是导致肺癌患者死亡的主要原因,且防控效率不高。近年来研究发现,免疫疗法或许是突破转移瓶颈的方向。巨噬细胞作为固有免疫的重要组成部分,参与肿瘤发生发展的全过程。肿瘤相关巨噬细胞(tumor-associated macrophages,TAMs)是肿瘤微环境(tumor microenvironment,TME)中最丰富的免疫群体,具有抗肿瘤的M1型和促肿瘤的M2型,后者通过促进肿瘤侵袭和转移、血管和淋巴管生成、免疫抑制和介导播散肿瘤细胞(disseminated tumor cells,DTCs)休眠重激活等途径促进肿瘤转移。近年来,中医药抑制肿瘤转移疗效显著并得到诸多验证,它能通过减少TAMs的募集、抑制M2型极化和调节TME中的细胞因子和蛋白发挥抗肿瘤作用。本文综述了TAMs与肺癌转移之间的关系,梳理了中医药调控TAMs防治肺癌转移的靶点与机制,以期为肺癌防治提供思路。Lung cancer is the leading cause of cancer-related deaths worldwide,with metastasis being the primary cause of mortality in lung cancer patients,and its prevention and control efficacy remain limited.In recent years,immunothera-py has emerged as a promising direction for overcoming the bottleneck of metastasis.Macrophages,as essential components of innate immunity,participate in the entire process of tumor initiation and progression.Tumor-associated macrophages(TAMs)represent the most abundant immune population in the tumor microenvironment(TME),displaying both anti-tumor M1-like and pro-tumor M2-like phenotypes.The latter promotes tumor invasion and metastasis,angiogenesis,lymphangiogenesis,immune suppression,and reactivation of dormant disseminated tumor cells(DTCs),thereby facilitating tumor metastasis.In recent years,traditional Chinese medicine(TCM)has shown significant efficacy in inhibiting tumor metastasis and has been extensively validated.It exerts anti-tumor effects by reducing the recruitment of TAMs,inhibiting M2-like polarization,and modulating cytokines and proteins in the TME.This paper reviews the relationship between TAMs and lung cancer metastasis,elucidates the targets and mechanisms of TCM in regulating TAMs to prevent and treat lung cancer metastasis,aiming to pro-vide insights into lung cancer prevention and treatment.

关 键 词：肿瘤相关巨噬细胞 极化 肺肿瘤 转移 中医药 

分 类 号：R273[医药卫生—中西医结合]