冬柏通淋合剂治疗慢性前列腺炎的临床观察  

Dongbai Tonglin Mixture for the treatment of chronic prostatitis

作　　者：刘娟[1] 夏伟[2] 袁泽焕 韩文均[2] LIU Juan;XIA Wei;YUAN Ze-huan;HAN Wen-jun(Department of Pharmacy,2.Department of Urology and Reproductive Medicine,The Seventh People's Hospital of Shanghai University of Chinese Medicine,Shanghai 200137,China)

机构地区：[1]上海中医药大学附属第七人民医院,药学部,上海200137 [2]上海中医药大学附属第七人民医院,泌尿生殖医学部,上海200137

出　　处：《中华男科学杂志》2024年第4期336-341,共6页National Journal of Andrology

基　　金：上海市卫生健康委员会科研项目(20214Y0280);上海市浦东新区卫生系统学科带头人培养计划项目(PWRd2020-08);上海市第七人民医院“七院名中医”人才培养计划项目(MZY2023-01)。

摘　　要：目的:评估冬柏通淋合剂治疗湿热下注型慢性前列腺炎(CP)的有效性。方法:选择76例湿热下注型CP患者随机分为2组,每组各38例。对照组口服前列泰片,治疗组口服冬柏通淋合剂,共治疗8周。分别在基线(治疗前)和第8周(治疗结束)后进行美国国立卫生研究院慢性前列腺炎症状评分(NIH-CPSI)和中医证候评分,并检测前列腺按摩液实验室指标。结果:治疗后两组NIH-CPSI总评分均较治疗前降低(P<0.05),且治疗组降低程度优于对照组(P<0.05)。其中,两组对排尿症状评分、疼痛和不适评分、生活质量评分均较治疗前降低(P<0.05),且治疗组改善情况均优于对照组(P<0.05)。两组前列腺中医证候评分均较治疗前显著降低(P<0.05),治疗组降低程度优于对照组(P<0.05),在改善尿不尽、少腹疼痛、会阴疼痛、阴囊潮湿方面尤为明显(P<0.05)。两组前列腺按摩液实验室指标中,白细胞(WBC)计数均较治疗前下降(P<0.05),卵磷脂小体(SPL)均较治疗前升高(P<0.05),治疗组对SPL的改善效果优于对照组(P<0.05)。治疗组总体有效率(88.89%)高于对照组(70.27%)(P<0.05)。结论:冬柏通淋合剂能有效治疗湿热下注型CP,可为临床应用提供参考。Objective:To evaluate the efficacy of Dongbai Tonglin Mixture(DTM)in the treatment of chronic prostatitis(CP)with the damp⁃heat downward diffusion syndrome.Methods:We randomly selected 76 cases of CP with the damp⁃heat downward dif⁃fusion syndrome,equally divided them into a DTM and a control group,and treated them by oral administration of DTM and Qianlie Tai Tablets,respectively,both for 8 weeks.We obtained the NIH⁃CPSI and TCM Syndrome Scores of the patients,recorded the counts of white blood cells(WBC)and small particles of lecithin(SPL)in the prostate fluid,and compared them between the two groups before and after treatment.Results:Compared with the baseline,the total NIH⁃CPSI scores were significantly reduced in both groups after treatment(P<0.05),particularly the scores on urination symptoms,pain/discomfort and quality of life(P<0.05),even more sig⁃nificantly in the DTM than in the control group(P<0.05),and so were the TCM Syndrome Scores(P<0.05),especially the scores on urinary incontinence,abdominal pain,perineal pain,and scrotal dampness(P<0.05),even more significantly in the former than in the latter group(P<0.05).The count of WBC in the prostate fluid was remarkably decreased(P<0.05),while that of SPL markedly increased in both groups after treatment(P<0.05),with an even more significant improvement in the DTM than in the con⁃trol group(P<0.05),and the overall effectiveness rate of treatment was significantly higher in the former group than in the latter(88.89%vs 70.27%,P<0.05).Conclusion:Dongbai Tonglin Mixture is effective for the treatment of CP with the damp⁃heat downward diffusion syndrome.

关 键 词：冬柏通淋合剂 慢性前列腺炎 湿热下注型 临床观察 

分 类 号：R697.33[医药卫生—泌尿科学]