益生菌抗流感病毒作用及其机制研究进展  

Research Progress on the Mechanism of Action of Probiotics Against Influenza Viruses

作　　者：赵佳明 李滢 吴毓薇 谢新强 吴清平 ZHAO Jiaming;LI Ying;WU Yuwei;XIE Xinqiang;WU Qingping(Shaanxi University of Science and Technology,School of Food Science and Engineering,Xi'an 710000,China;Institute of Microbiology,Guangdong Academy of Sciences,State Key Laboratory of Applied Microbiology Southern China,Guangdong Provincial Key Laboratory of Microbial Safety and Health,National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food,Guangzhou 510000,China;Guangdong Kehuan Biotechnology Co,Ltd,Guangzhou 510525,China)

机构地区：[1]陕西科技大学食品科学与工程学院,西安710000 [2]广东省科学院微生物研究所华南应用微生物国家重点实验室广东省微生物安全与健康重点实验室国家卫健委微生物食品营养与安全科技创新平台,广州510000 [3]广东科环生物科技有限公司,广州510525

出　　处：《病毒学报》2024年第4期877-886,共10页Chinese Journal of Virology

基　　金：国家重点研发计划项目(项目号:2022YFD2100703),题目:高产有益代谢产物乳酸菌的精准筛选及特征代谢产物功能解析和制造关键技术;广东省重点研发专项(项目号:2022B1111070006),题目:重要健康微生物菌种定向选育及功能产品研发;广东省科学院项目(项目号:2022GDASZH⁃2022020402⁃01),题目:广东省科学院海南院士创新中心建设。

摘　　要：流行性感冒是一种由流感病毒引起的急性呼吸道传染病。在高危人群中,严重的病毒感染可导致下呼吸道感染、多器官功能衰竭,甚至死亡。益生菌是一种能提升人体健康的功能微生物,具有防止病原微生物定植、调节宿主免疫等功能。目前已有多项研究发现某些益生菌具有防治流感病毒感染的作用,且近年来关于益生菌抗流感病毒的机制研究已有了一些探索,因此,在系统解析流感病毒致病机制的基础上,本文从病毒拮抗、免疫调节、预防继发感染和平衡肠道微生态4个角度总结了抗流感病毒益生菌的作用机制,进而探讨益生菌抗流感病毒的应用模式,以期对益生菌抗流感病毒的应用提供参考。Influenza is an acute infection of the respiratory tract.After entering the human body,a particular influenza virus attacks various tissues and organs.If the infection is severe,it can,lead to multiple⁃organ failure,shock,and death.Probiotics are functional microorganisms that can prevent the colonization of pathogenic microorganisms and regulate host immunity.Several studies have found that some probiotics can prevent and treat influenza⁃viruses infection.In recent years,there have been explorations on how probiotics act against influenza viruses.Herein we summarize how probiotics act against influenza viruses from four aspects:virus antagonism;immune regulation;prevention of secondary infection;balance of intestinal microecology.Also,we discuss the application mode of probiotics against influenza virus to provide a reference for future research.

关 键 词：流感病毒 发病机制 益生菌 微生态 免疫调控 

分 类 号：R183.3[医药卫生—流行病学]