EB病毒的生物学特点及致病机制  

Biological Characteristics and Pathogenesis of the Epstein-Barr Virus

作　　者：刘军[1] 邓世明[1] 刘铁陵[1] 何顺芬 唐洪[1] 卢蓉蓉 LIU Jun;DENG Shiming;LIU Tieling;HE Shunfen;TANG Hong;LU Rongrong(Mianyang Traditional Chinese Medicine Hospital,Mianyang 621000,China)

机构地区：[1]绵阳市中医医院,绵阳621000

出　　处：《病毒学报》2024年第4期887-896,共10页Chinese Journal of Virology

摘　　要：EB病毒(Epstein‒Barr virus,EBV)是一种DNA病毒,EB病毒感染在世界范围内常见,人群普遍易感,在我国主要影响学龄期儿童和青少年。该病毒可以通过潜伏感染的形式贮存于记忆性B细胞中,逃避人体免疫系统识别,使机体处于终身携带病毒状态。EB病毒与许多疾病有关,严重影响人类健康。本综述重点介绍了EBV的生物学特点及致病机制,关注了该病毒如何与其宿主在肿瘤发生过程中的相互作用。The Epstein‒Barr virus(EBV)is a DNA virus.It is found commonly worldwide.The EBV can infect susceptible members of the general population.It mainly affects school-age children and adolescents in China.The EBV can be stored in memory B cells through latent infection,evading recognition by the human immune system and placing the body in a lifelong“carrier”state.The EBV is associated with several diseases and seriously affects human health.This review focuses on:(i)the biological characteristics and pathogenesis of the EBV;and(ii)how the EBV interacts with its host during tumor development.

关 键 词：EB病毒 免疫逃逸 致病机制 癌症诱导 淋巴瘤 上皮癌 

分 类 号：R373.9[医药卫生—病原生物学]