人乳头瘤病毒型别竞争与型别替换的流行病学研究进展  

Research Progress of Human Papillomavirus(HPV)Type Competition and Type Replacement

作　　者：陈雨[1,2] 周裕林 姚星妹 CHEN Yu;ZHOU Yulin;YAO Xingmei(Department of Central Laboratory,Women and Children’s Hospital,School of Medicine,Xiamen University,Xiamen 361003,China;Public Health School of Xiamen University,Xiamen 361102,China)

机构地区：[1]厦门大学附属妇女儿童医院(厦门市妇幼保健院)中心实验室,厦门3610031 [2]厦门大学公共卫生学院,厦门361003

出　　处：《病毒学报》2024年第4期914-920,共7页Chinese Journal of Virology

基　　金：福建省卫生健康科技计划项目(项目号:2022QNB022),题目:闽南地区高危型人乳头瘤病毒流行病学特征及传播动力学研究。

摘　　要：人乳头瘤病毒(Human papillomavirus,HPV)是最常见的性传播病原体,可导致多种癌症,目前已经发现200多种基因型。预防性HPV疫苗有望减少甚至消灭由疫苗型别导致的疾病负担,但目前的疫苗并未覆盖HPV所有型别,人们始终关注广泛实施HPV疫苗接种后,疫苗型别流行率降低空出的生态位是否将被非疫苗型别替代?目前对于HPV疫苗接种后是否存在型别替换的研究也取得了一定进展。本文拟对HPV疫苗型别竞争与型别替换的研究进展做一综述。Human papillomavirus(HPV)is one of the most common sexually transmitted pathogens,causing various cancers,and more than 200 HPV genotypes have been identified.The HPV vaccine is expected to eventually reduce or eliminate the burden of diseases attributable to HPV vaccine type.However,current vaccines do not cover all types of HPV.A concern has been raised that it may lead to type replacement following widely implementing HPV vaccination programs.Progress has been made in researching type replacement following HPV vaccination.Here,we review the research progress on the HPV type competition and type replacement.

关 键 词：人乳头瘤病毒(Human papillomavirus HPV) 型别竞争 型别替换 

分 类 号：R373.9[医药卫生—病原生物学]