STEMI患者超敏C反应蛋白水平与TIMI血流分级及Gensini评分的关系  

Relationship Between High-sensitivity C-reactive Protein Level and TIMI Blood Flow Grading and Gensini Score in STEMI Patients

作　　者：萨如拉 高雯[2] 周志宏[2] Sarua;GAO Wen;ZHOU Zhihong(Baotou Medical College,Baotou 014000 China;The Bayannur Hospital,Bayannur 015000 China)

机构地区：[1]内蒙古科技大学包头医学院,内蒙古包头014000 [2]巴彦淖尔市医院,内蒙古巴彦淖尔015000

出　　处：《内蒙古医学杂志》2024年第7期890-895,共6页Inner Mongolia Medical Journal

基　　金：巴彦淖尔市医院院内科研项目计划任务(编号:2022004)。

摘　　要：目的探讨急性ST段抬高型心肌梗死(STEMI)患者的超敏C反应蛋白水平与TIMI血流分级及Gensini评分的关系。方法收集2021年1-12月巴彦淖尔市医院行急诊PCI治疗的STEMI患者288例,根据TIMI血流分级及Gensini评分将研究对象分为A组(TIMI 0~1级186例)和B组(TIMI 2~3级102例)、轻度组(Gensini评分≤81分145例)和重度组(Gensini评分>81分143例),比较临床资料,分析hs-CRP水平与STEMI患者PCI术前冠脉血流分级降低及冠状动脉病变程度相关性。结果TIMI 2~3级患者的hs-CRP水平明显低于TIMI 0~1级患者(P=0.01),且Spearman相关系数法分析结果显示血清hs-CRP与术前TIMI血流呈显著负相关(r=-0.174,P<0.01),多因素回归分析的结果表明,hs-CRP是TIMI血流降低的危险因素(OR=0.819,95%CI:0.683~0.982,P<0.05),提示hs-CRP是术前TIMI血流降低的预测因子。轻度组血清hs-CRP水平小于重度组(P<0.05),且Spearman相关系数法分析结果显示hs-CRP与STEMI患者Gensini评分呈正相关(r=0.140,P=0.017),表明患者hs-CRP水平越高,Gensini评分越高。结论本研究发现hs-CRP水平与STEMI患者术前TIMI血流降低及Gensini评分有显著相关性。Objective To investigate the relationship between high-sensitivity C-reactive protein level and TIMI blood flow grading and Gensini score in STEMI patients.Methods A total of 288 STEMI patients who underwent emergency PCI in Bayannur City Hospital from January 2021 to December 2021 were collected,and the study subjects were divided into Group A(TIMI grade O-1186 cases)and Group B(TIMI grade 2-3102 cases),mild(Gensini score≤81145 cases)and severe(Gensini score>81 points 143 cases),respectively,compared the clinical data of patients in the two groups and analyze the correlation between hs-CRP levels and pre-PCI coronary flow grade reduction and degree of coronary artery disease in STEMI patients.Results The hs-CRP levels of patients with TIMI grades 2-3 were significantly lower than those of patients with TIMI grades 0-1(P=0.01),and the results of the Spearman correlation coefficient method showed a significant negative correlation between serum hs-CRP and preoperative TIMI blood flow(r=-0.174,P<0.01),and the results of the multifactorial regression analysis indicated that hs-CRP was a TIMI blood flow risk factor for decreased TIMI blood flow(OR=0.819,95%CI:0.683-0.982,P<0.05),suggesting that hs-CRP was a predictor of decreased preoperative TIMI blood flow.In addition,the level of serum hs-CRP in patients in the mild group was smaller than that in patients in the severe group(P<0.05),and the results of Spearman's cor-relation coefficient method analysis showed a positive correlation between hs-CRP and Gensini scores of patients with STEMI(r=0.140,P=0.017),which indicated that the higher the level of hs-CRP in the patients,the higher the Gensini scores were.Conclusion In this study,we found a significant correlation between hs-CRP levels and preoperative TIMI blood flow reduction and Gensini score in STEMI patients.

关 键 词：急性ST段抬高型心肌梗死 超敏C反应蛋白 心肌梗死溶栓血流分级 GENSINI评分 

分 类 号：R541.4[医药卫生—心血管疾病]